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Navigator on the Digital Space of Scientific Knowledge of the Ural Region: Concept and Structure
БиблиосфераOne of the key areas of the state policy in the field of scientific and technological development of the country is to create an infrastructure and conditions for conducting research and implementing high-tech technologies.
A. Yu. Gerasimenko
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Tools for Navigating Today's Labor Market: A Vital Role for States [PDF]
, 2008 Individuals need easily accessible, easy-to-understand information to successfully navigate the ever-changing U.S. labor market. Internet tools are one way to effectively and efficiently convey such information to users.
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Alaska Resources Library and Information Services: Pioneering Partnerships on the Last Frontier [PDF]
, 2008 This is an Accepted Manuscript of an article published by Taylor & Francis in Science and Technology Libraries on September 2008, available online: http://www.tandfonline.com/ 10.1300/J122v24n01_08Five federal agencies, one state agency, one state ...
Braund-Allen, Juli, Carle, Daria O.
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Digital information support for concept design [PDF]
, 2010 This paper outlines the issues in effective utilisation of digital resources in conceptual design. Access to appropriate information acts as stimuli and can lead to better substantiated concepts.
Ion, William, Wodehouse, Andrew
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Information resources on nanotechnology
Библиосфера, 2012 The sources of scientific and technological information necessary for research and development in the field of nanotechnology are investigated.
L. B. Shevchenko
doaj
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
Academic libraries and learning support in the electronic environment [PDF]
, 2004 Learning and teaching techniques are changing in the new electronic environment. Students are asked to gather information from different sources, most of them in electronic formats. Libraries have to adapt their buildings and services to meet their users
Serrano-Vicente, Rocio
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FEBS Open Bio, EarlyView.Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu +8 more
wiley +1 more source