Results 91 to 100 of about 7,826,212 (327)

Computer-based library or computer-based learning? [PDF]

open access: yes, 2010
Traditionally, libraries have played the role of repository of published information resources and, more recently, gateway to online subscription databases. The library online catalog and digital library interface serve an intermediary function to help
Khoo, S.G. Christopher
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

USING INTERNET SOURCES IN TEACHING ECONOMIC SUBJECTS

open access: yesВысшее образование в России, 2016
This paper examines the possibility of increasing the efficiency of the learning process by using economic and scientific information sources. The authors demonstrate that for improving the quality of higher education it is necessary to use Internet ...
Svetlana V. Kulikova   +1 more
doaj  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

ON SOME PROSPECTS FOR THE DEVELOPMENT OF E-GOVERNMENT IN THE CONDITIONS OF DIGITAL TRANSFORMATION

open access: yesГуманитарные и юридические исследования, 2021
The article is devoted to the analysis of basic directions of the development of e-government, as well as the possibilities for the practical implementation of the new principle of "digital defaults" in the provision of public services.
Elena Kholodnaya
doaj  

An Exploratory Study of Online Information Regarding Colony Collapse Disorder [PDF]

open access: yes, 2012
The cause or causes of Colony Collapse Disorder (CCD) are uncertain. CCD defines specific characteristics of the nationwide deaths of honey bee colonies in the last decade.
Boehm, Meredith K.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Ground-water records of Flagler, Putnam, and St. Johns Counties, Florida [PDF]

open access: yes, 1963
An investigation of the geology] and ground-water resources of Flagler, Putnam, and St. Johns counties, Florida, was made during the period November 1955 through 1958 by the U. S.
Bermes, B. J.   +2 more
core  

Confronting The Challenge Of Information Literacy

open access: yes, 2003
Confronting the challenges to any academic institution posed by the revolution in information resources since the appearance of the Internet can be a daunting task.
Baker, Steven L.
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

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