Results 71 to 80 of about 21,543,109 (289)
Effects of corruption risks on access to information resources: the question
Проблеми Законності, 2015 The article examines the impact of actual corruption risks in providing access to information resources. Defined objective and subjective factors contributing to the corruption risks and the ways of their reduction.
О. Б. Червякова
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Herland Sister Resources : v.1: no.4(1985)
, 1985 The Herland Sister Resources newsletter is the monthly publication of Herland Sister Resources, a womanist organization with a strong lesbian focus based in Oklahoma ...
Herland Sister Resources
core
Navigator on the Digital Space of Scientific Knowledge of the Ural Region: Concept and Structure
БиблиосфераOne of the key areas of the state policy in the field of scientific and technological development of the country is to create an infrastructure and conditions for conducting research and implementing high-tech technologies.
A. Yu. Gerasimenko
doaj +1 more source
Equitable School Library Services for Students with Dyslexia in Nigeria
Bilgi Dünyası, 2018 The paper attempts to establish ways in which school libraries in Nigeria can make available the right information resources to students suffering from dyslexia. Dyslexia is a mental disability and individuals that are dyslexic find it difficult to read,
Oyeronke Adebayo +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Herland Sister Resources : v.4: no.12(1987)
, 1987 The Herland Sister Resources newsletter is the monthly publication of Herland Sister Resources, a womanist organization with a strong lesbian focus based in Oklahoma ...
Herland Sister Resources
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Herland Sister Resources : v.1: no.7(1985)
, 1985 The Herland Sister Resources newsletter is the monthly publication of Herland Sister Resources, a womanist organization with a strong lesbian focus based in Oklahoma ...
Herland Sister Resources
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source