Results 81 to 90 of about 7,089,576 (325)

Information Resources Importance and Format Inclination of Science and Technology Researchers

open access: yesInternational Journal of Information Science and Management, 2020
This study examined important information resources and format inclination of information resources utilized by science and technology (S&T) researchers as they acquire information in the course of their projects.
Olayinka B. Makinde Makinde   +2 more
doaj  

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

COMMERCIALIZATION OF INNOVATIVE ACTIVITIES AND ESSENCE OF INNOVATIVE ENTREPRENEURSHIP

open access: yesAdvanced Engineering Research, 2011
The conceptual framework of commercialization in the market system is revealed. The essence of the innovation business in the regulation of the commercial innovative activities is analyzed.
Boris М. Getman   +2 more
doaj  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

'ZOOMing' in on Consulting with Children and Parents Remotely to Co-Create Health Information Resources. [PDF]

open access: yesChildren (Basel), 2023
Saron H   +8 more
europepmc   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Publicly Available Information on the Internet and the Specifics of its Use by Journalists. Legal Aspects

open access: yesIzvestiâ Ûžnogo Federalʹnogo Universiteta: Filologičeskie Nauki, 2019
The article deals with controversial issues related to the use of public information on the Internet, the interpretation of the terms “access to information” and “use of information”.
Anna G. Donskikh
doaj   +1 more source

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