Results 71 to 80 of about 5,261,148 (345)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Designing a site-directory of web resources for a teacher of informatics

open access: yesUkrainian Journal of Educational Studies and Information Technology, 2019
The article is devoted to the study of the process of creating and designing a site-catalogue of modern web resources for its usage by informatics teacher in his professional activities.
Viktoriia Alekseienko, Olena Usata
doaj   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Librarian Recommended: A Survey of Engineering Education Resources in Library Research Guides

open access: yesIssues in Science and Technology Librarianship
Through content analysis, this study identifies the information resources frequently included in Engineering Education Research (EER) library research guides from universities with very high research activity.
Allyson Wood
doaj   +1 more source

informing the general public about cell migration a public engagement resource

open access: yes, 2013
Outreach activities become an increasingly important part of a researcher's life, out of social responsibility as well as to meet expectations by research funding institutions. Yet, outreach activities are little supported by resources which provide guidance, strategies, examples and materials, and researchers are widely left alone with the task of re ...
Sumner, Jessica, Prokop, Andreas
openaire   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Classical capacity per unit cost for quantum channels

open access: yes, 2017
In most communication scenarios, sending a symbol encoded in a quantum state requires spending resources such as energy, which can be quantified by a cost of communication.
Jarzyna, Marcin
core   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

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