Results 11 to 20 of about 727,136 (175)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
Large scale evaluations of multimedia information retrieval: the TRECVid experience [PDF]
, 2005 Information Retrieval is a supporting technique which underpins a broad range of content-based applications including retrieval, filtering, summarisation, browsing, classification, clustering, automatic linking, and others.
G. Kazai, J.G. Fiscus
core +2 more sources
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Retrieving with good sense [PDF]
, 2000 Although always present in text, word sense ambiguity only recently became regarded as a problem to information retrieval which was potentially solvable.
Sanderson, M.
core +2 more sources
Accessibility in Information Retrieval [PDF]
, 2008 This paper introduces the concept of accessibility from the field of transportation planning and adopts it within the context of Information Retrieval (IR). An analogy is drawn between the fields, which motivates the development of document accessibility measures for IR systems. Considering the accessibility of documents within a collection given an IR
Vishwa Vinay, Leif Azzopardi
openaire +3 more sources
Quantum Advantage in Information Retrieval
PRX Quantum, 2022 Random access codes have provided many examples of quantum advantage in communication, but concern only one kind of information retrieval task. We introduce a related task – the Torpedo Game – and show that it admits greater quantum advantage than the comparable random access code. Perfect quantum strategies involving prepare-and-measure protocols with
Pierre-Emmanuel Emeriau +2 more
openaire +5 more sources
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Information retrieval system [PDF]
, 1970 Generalized information storage and retrieval system capable of generating and maintaining a file, gathering statistics, sorting output, and generating final reports for output is reviewed.
Berg, R. F. +4 more
core +1 more source