Results 41 to 50 of about 16,556,741 (301)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Optimizing feature straction for Symbolic Music

open access: yes, 2023
This paper presents a comprehensive investigation of existing feature extraction tools for symbolic music and contrasts their performance to determine the set of features that best characterizes the musical style of a given music score.
Torrente Sánchez-Guisande, Álvaro José   +6 more
core  

A Framework for Evaluating the Retrieval Effectiveness of Search Engines [PDF]

open access: yes, 2012
This chapter presents a theoretical framework for evaluating next generation search engines. We focuson search engines whose results presentation is enriched with additional information and does notmerely present the usual list of “10 blue links”, that ...
Lewandowski, Dirk   +4 more
core   +1 more source

Explainable online health information truthfulness in Consumer Health Search

open access: yesFrontiers in Artificial Intelligence, 2023
IntroductionPeople are today increasingly relying on health information they find online to make decisions that may impact both their physical and mental wellbeing.
Rishabh Upadhyay   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Priors for Diversity and Novelty on Neural Recommender Systems

open access: yesProceedings, 2019
PRIN is a neural based recommendation method that allows the incorporation of item prior information into the recommendation process. In this work we study how the system behaves in terms of novelty and diversity under different configurations of item ...
Alfonso Landin   +3 more
doaj   +1 more source

Tree Crowns Segmentation and Classification in Overlapping Orchards Based on Satellite Images and Unsupervised Learning Algorithms

open access: yesJournal of Imaging, 2021
Smart agriculture is a new concept that combines agriculture and new technologies to improve the yield’s quality and quantity as well as facilitate many tasks for farmers in managing orchards.
Abdellatif Moussaid   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Ten years of MIREX: reflections, challenges and opportunities [PDF]

open access: yes, 2014
The Music Information Retrieval Evaluation eXchange (MIREX) has been run annually since 2005, with the October 2014 plenary marking its tenth iteration.
Lee, Jin Ha   +11 more
core  

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