Results 61 to 70 of about 11,220,818 (306)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Anserini: Enabling the Use of Lucene for Information Retrieval Research

Annual International ACM SIGIR Conference on Research and Development in Information Retrieval, 2017
Software toolkits play an essential role in information retrieval research. Most open-source toolkits developed by academics are designed to facilitate the evaluation of retrieval models over standard test collections.
Peilin Yang, Hui Fang, Jimmy J. Lin
semanticscholar   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Comparative evaluation of generative audio models for precise disease classification via sound-based datasets

Journal of Big Data
Generative models play a pivotal role in speech and audio generation, and recent advancements have expanded their applications in medical diagnosis. This study provides a comprehensive comparative analysis of various generative models, focusing on their ...
Esraa Hassan, Nora El-Rashidy
doaj   +1 more source

Information Retrieval - From Information Access to Contextual Retrieval

, 2020
Information Retrieval (IR) deals with uncertainty and vagueness in in-formation systems. Uncertainty is caused by the problem of representing the semantics of text and other media, which cannot be done in a perfect way. On the other hands, information needs to be answered by IR systems are often vague and cannot be specified precisely, thus leading to ...
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

An ECC with error detection and against side channel attacks for resource constrained devices

Journal of King Saud University: Computer and Information Sciences
As more devices are integrated into the Internet of Things (IoT) ecosystem, accurate and efficient information transmission between resource-constrained equipment has become particularly important.
Jun Ye, Zewen Yang
doaj   +1 more source

An efficient long-text semantic retrieval approach via utilizing presentation learning on short-text

Complex & Intelligent Systems, 2023
Although the short-text retrieval model by BERT achieves significant performance improvement, research on the efficiency and performance of long-text retrieval still faces challenges.
Junmei Wang, Jimmy X. Huang, Jinhua Sheng   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Explainable self-supervised learning for medical image diagnosis based on DINO V2 model and semantic search

Scientific Reports
Medical images have become indispensable for decision-making and significantly affect treatment planning. However, increasing medical imaging has widened the gap between medical images and available radiologists, leading to delays and diagnosis errors ...
Alaa Hussien, Abdelkareem Elkhateb, Mai Saeed, Nourhan M. Elsabawy, Alaa Ebraheem Elnakeeb, Nora Elrashidy   +5 more
doaj   +1 more source