Results 71 to 80 of about 16,556,741 (301)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Desensitization of Private Text Dataset Based on Gradient Strategy Trans-WTGAN

Tsinghua Science and Technology
Privacy-sensitive data encounter immense security and usability challenges in processing, analyzing, and sharing. Meanwhile, traditional privacy data desensitization methods suffer from issues such as poor quality and low usability after desensitization.
Zhen Guo, Ying Zhou, Jun Ye, Yongxu Hou
doaj   +1 more source

Information Retrieval - From Information Access to Contextual Retrieval

, 2020
Information Retrieval (IR) deals with uncertainty and vagueness in in-formation systems. Uncertainty is caused by the problem of representing the semantics of text and other media, which cannot be done in a perfect way. On the other hands, information needs to be answered by IR systems are often vague and cannot be specified precisely, thus leading to ...
openaire   +2 more sources

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Cross-lingual Information Retrieval based on Multiple Indexes [PDF]

, 2009
Sorg P, Braun M, Nicolay D, Cimiano P. Cross-lingual Information Retrieval based on Multiple Indexes.
Sorg, Philipp, Braun, Marlon, Nicolay, David, Cimiano, Philipp ; https://orcid.org/   +3 more
core  

How capable are large language models in specialized medical domains? The case of Hashimoto’s thyroiditis

Natural Language Processing Journal
To systematically assess the accuracy, completeness, and safety of information provided by three mainstream LLMs (ChatGPT-5, DeepSeek-V3.2, Gemini-2.5 Flash) regarding Hashimoto’s Thyroiditis (HT), a set of standardized clinical questions was designed ...
Li Zeng, Ellen Huang, Yizheng Huang
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

An ECC with error detection and against side channel attacks for resource constrained devices

Journal of King Saud University: Computer and Information Sciences
As more devices are integrated into the Internet of Things (IoT) ecosystem, accurate and efficient information transmission between resource-constrained equipment has become particularly important.
Jun Ye, Zewen Yang
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source