Results 61 to 70 of about 890,500 (271)
Performance comparison of clustered and replicated information retrieval systems [PDF]
, 2007 The amount of information available over the Internet is increasing daily as well as the importance and magnitude of Web search engines. Systems based on a single centralised index present several problems (such as lack of scalability), which lead to the
Cacheda, F. +3 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Large Scale Question Paraphrase Retrieval with Smoothed Deep Metric Learning
, 2019 The goal of a Question Paraphrase Retrieval (QPR) system is to retrieve equivalent questions that result in the same answer as the original question. Such a system can be used to understand and answer rare and noisy reformulations of common questions by ...
Bonadiman, Daniele +2 more
core +1 more source
A methodology to allow avalanche forecasting on an information retrieval system [PDF]
, 1998 This paper presents adaptations and tests undertaken to allow an information retrieval (IR) system to forecast the likelihood of avalanches on a particular day.
Buser O +8 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Evaluating epistemic uncertainty under incomplete assessments [PDF]
, 2007 The thesis of this study is to propose an extended methodology for laboratory based Information Retrieval evaluation under incomplete relevance assessments.
Barry +25 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Ensuring Information Security and Factographic Systems
Безопасность информационных технологий, 2015 This article is about methods of information security. These methods are a part of the automated tools of ensuring the information security. It is offered to use a factographic information retrieval. The results are protected with patents.
Sergey Dmitrievich Kulik
doaj
Perspectivas em Ciência da InformaçãoEste estudo apresenta uma síntese bibliográfica sobre as metodologias de avaliação que foram propostas por pesquisadores internacionais e nacionais e utilizadas por indexadores de instituições de ensino e/ou pesquisas atuantes em unidades de informação e/
Vera Regina Casari Boccato +1 more
doaj +1 more source