Results 171 to 180 of about 10,648,550 (267)

Cannabis produces acute hyperphagia in humans and rodents via increased reward valuation for, and motivation to, acquire food. [PDF]

Proc Natl Acad Sci U S A
Hume C, Cuttler C, Baglot SL, Javorcikova L, McLaughlin RJ, Hill MN.   +5 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Examining the influence of two emotion regulation strategies on anxiety in Chinese college students: insights from cross-lagged and moderated network models. [PDF]

BMC Psychol
Zou X, Lv Y, Tang Q, Wang S, Liu X, Zhang L, Tao Y, Zhou J.   +7 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Plant cognition after Darwin: historical and epistemological remarks. [PDF]

Hist Philos Life Sci
Pecere P.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-in-Schizophrenia 1 (DISC1). [PDF]

J Neurosci
Dören J, Kupriyanova Y, Schäble S, Troßbach S, McGuire B, Vernon AC, Roden M, Korth C, Kalenscher T.   +8 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Building Goal-Directed Cognitive Graphs

Gungi A, Sepúlveda P, Aitsahalia IF, Blanco-Pozo M, Iigaya K.   +4 more
europepmc   +1 more source

Emotional Impairments in Animal Models of Traumatic Neuropathic Pain: Where Do We Stand? [PDF]

Biol Psychiatry Glob Open Sci
Pinto-Ribeiro F.
europepmc   +1 more source