Results 81 to 90 of about 2,499 (218)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Helicobacter pylori: types of diseases, diagnosis, treatment and causes of therapeutic failure
Journal of Mind and Medical Sciences, 2016 Acute upper gastrointestinal lesions have a multifactorial etiology but, regardless of the cause, they are related to mucosal barrier destruction. Since Helicobacter pylori induces a superficial chronic gastritis with the infiltration of neutrophils in ...
Cosmin Vasile Obleaga +4 more
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Sosyal Ekonomik Araştırmalar Dergisi, 2003 Küresel ekonomik yapı iş dünyasının çevresel koşullarını dönüştürmektedir. Işletmeler hızla değişen çevresel ortama uygun yönetsel politikalar uygulayarak tepki vermektedir.
Süleyman AÇIKALIN
doaj +2 more sources
ANALISIS IMPLEMENTASI SAK ETAP MENJADI SAK EP: STUDI KOMPARATIF PERUSAHAAN MANUFAKTUR DAN JASA
Riset AkuntansiThis research aims to examine the effects of implementing the new financial accounting standard—Standar Akuntansi Keuangan Entitas Privat (SAK EP), or Financial Accounting Standards for Private Entities—on the financial reporting practices of two ...
Abhyasa Sulthan Madaharsa +1 more
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
La Calidad de la Información Fiscal en las Empresas del IBEX-35
Revista de Contabilidad: Spanish Accounting Review, 2006 En el actual proceso de adaptación de la normativa española a las Normas Internacionales de Contabilidad, el futuro tratamiento contable del Impuesto sobre Sociedades supone mayores exigencias de información, lo que conlleva nuevas obligaciones formales ...
Julián Martínez Vargas +1 more
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