Results 191 to 200 of about 24,852,160 (385)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Novel extensions of k-harmonically convex functions and their applications in information science. [PDF]

PLoS One
Fahad A, Furuichi S, Ali Z, Wang Y.
europepmc   +1 more source

Incorporating Geographic Information Science and Technology in Response to the COVID-19 Pandemic. [PDF]

Prev Chronic Dis, 2020
Smith CD, Mennis J.
europepmc   +1 more source

Proceedings of the U.S. Geological Survey Eighth Biennial Geographic Information Science Workshop and first The National Map Users Conference, Denver, Colorado, May 10-13, 2011 [PDF]

, 2014

openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Quantum Information Science Challenge for Chemistry. [PDF]

J Phys Chem Lett
Scholes GD, Olaya-Castro A, Mukamel S, Kirrander A, Ni KK, Hedley GJ, Frank NL.   +6 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Das liest die LIBREAS, Nummer #1 (Sommer / Herbst 2017)

Library Ideas, 2017
Redaktion LIBREAS
doaj   +1 more source

Quantum Models of Consciousness from a Quantum Information Science Perspective. [PDF]

Entropy (Basel)
Gassab L, Pusuluk O, Cattaneo M, Müstecaplıoğlu ÖE.   +3 more
europepmc   +1 more source

Reimagining information science and technology beyond traditional boundaries in the global coronavirus pandemic situation. [PDF]

Proc Assoc Inf Sci Technol, 2020
Rorissa A, Li M, Young M, Turetsky D, Yuan XJ.   +4 more
europepmc   +1 more source