Results 41 to 50 of about 3,597,064 (317)

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Philosophy and Information Science

open access: yes, 2018
Looking out of Information Science (IS) it´s a dangerous attempt to compare this relative new science direct with Philosophy. Here you find a first circumspective trial of an investigation of the traditionally named “queen of science”, Philosophy, two thousand years old and - direct opposite - the only a half century old Information Science. For me it
openaire   +4 more sources

Informing policy with science [PDF]

open access: yesScience, 2017
We recently witnessed the peaceful—if controversial—transition of the United States presidency. As with any major change in federal government, the scientific community has concerns about new directions and priorities that may affect the way science is conducted, funded, and used in the United States and elsewhere.
openaire   +3 more sources

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Information Science: Science about Information Misinformation and Disinformation [PDF]

open access: yesInSITE Conference, 2003
Participants in interactions (particularly in interactive network media (WWW) aim to change their intentions, goals, decisions and actions - as well as those of other participants in communication. Integrity of information is therefore disturbed; changes are manifested as technical, semantic and social errors and lead to the creation of information ...
Miroslav Tudjman, Nives Mikelic
openaire   +3 more sources

information science

open access: yes, 2022
avaliação de palavras correlacionadas e autores da área de ciência da informação.
openaire   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Tiempos normales o posnormales para la Ciencia de la Información = Normal or post-normal times for Information Science

open access: yesInformación, Cultura y Sociedad, 2021
En este Editorial se realiza una revisión de las perspectivas que intentan describir los conceptos producidos en la investigación científica y tecnológica en relación con la “ciencia posnormal”.
Nancy Blanco
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

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