Results 71 to 80 of about 4,571,992 (304)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Summary of Research 2001, Department of Information Science [PDF]

open access: yes, 2001
The view expressed in this report are those of the authors and do not reflect the official policy or position of the Department of Defense or U.S. Government.This report contains project summanes of the research projects in the Department of Information
Faculty of the Naval Postgraduate School Department of Information Science
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Forecasting the Subject Trend of International Library and Information Science Research by 2030 Using the Deep Learning Approach

open access: yes, 2022
This study seeks to forecast the subject trend of library and information science research until 2030 based on modeling previous research topics in this field, which has been done with a text mining and in-depth learning approach.
Ghane, Mohammad Reza; Associate Prof. of LIS, Department of Evaluation and Collection Development, Regional Information Center for Science & Technology (RICeST), Shiraz, Iran   +2 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Rediscovering Don Swanson:The Past, Present and Future of Literature-based Discovery

open access: yesJournal of Data and Information Science, 2017
The late Don R. Swanson was well appreciated during his lifetime as Dean of the Graduate Library School at University of Chicago, as winner of the American Society for Information Science Award of Merit for 2000, and as author of many seminal articles ...
Smalheiser Neil R.
doaj   +1 more source

Using Ensemble Machine Learning and Feature Engineering to Increase the Accuracy of Predicting Learners' Performance in an Online Educational Environment [PDF]

open access: yesInterdisciplinary Journal of Virtual Learning in Medical Sciences
Background: Online training has gained popularity as an effective teaching method, necessitating diligent monitoring of learner progress and engagement. The challenge of predicting academic performance in online courses is crucial for supporting learners
Seyede Fatemeh Noorani   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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