Results 81 to 90 of about 45,109,686 (250)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Das liest die LIBREAS, Nummer #9 [Herbst / Winter 2021]

Library Ideas, 2021
Redaktion LIBREAS
doaj   +1 more source

Retracted: Hotspot Mining in the Field of Library and Information Science under the Environment of Big Data. [PDF]

J Environ Public Health, 2023
Environmental And Public Health JO.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The outlook of final-year students in information science on the world of work

South African Journal of Information Management
Background: The principle of co-creation in curriculum design has become fundamental in recent times, necessitating the multiplicity of relevant voices to speak into curriculum design.
Martie A. Mearns, Elmi Bester
doaj   +1 more source

Geographic information science in the era of geospatial big data: A cyberspace perspective. [PDF]

Innovation (Camb), 2022
Liu X, Chen M, Claramunt C, Batty M, Kwan MP, Senousi AM, Cheng T, Strobl J, Arzu C, Wilson J, Bandrova T, Konecny M, Torrens PM, Zhang F, He L, Wang J, Ratti C, Kolditz O, Klippel A, Li S, Lin H, Lü G.   +21 more
europepmc   +1 more source

Health information science and technology education: An analysis of health informatics undergraduate and postgraduate programs in arab countries. [PDF]

Heliyon, 2023
Almehmadi FM.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Factors affecting time to publication in information science. [PDF]

Scientometrics, 2022
Taşkın Z, Taşkın A, Doğan G, Kulczycki E.   +3 more
europepmc   +1 more source