Results 221 to 230 of about 899,494 (294)

RaPID Selection of Backbone Macrocyclic Peptides Targeting Akt2. [PDF]

Angew Chem Int Ed Engl
Shinbara K, Yanagi E, Aizawa A, Katoh T, Suga H.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

RETRACTION: Frequent Alterations of the Candidate Genes hMLH1, ITGA9 and RBSP3 in Early Dysplastic Lesions of Head and Neck: Clinical and Prognostic Significance. [PDF]

Cancer Sci
europepmc   +1 more source

DIAG: A Framework for Evaluating Whole-Genome Amplification Quality in Single-Cell SNV Analysis. [PDF]

Biology (Basel)
Zhang D, Zhang M, Zhang A, Yang S, Huang W, Cao T, Bu X, Liu Z, Chen B, Deng S.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A portrait of commissioned literature: connecting the dots between medical education and communication companies, authors, funders and publishers. [PDF]

Res Integr Peer Rev
Bernisson M.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A chromosome-level genome assembly of the Leschenault's rousette (Rousettus leschenaultii). [PDF]

Sci Data
Chen L, Yang G, Hou S, Chai S.
europepmc   +1 more source