Results 61 to 70 of about 281,646 (307)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Physicists' information behavior: a qualitative study of users [PDF]

open access: yes, 2004
The work analyzes information seeking behavior of students who are in the process of getting a PhD in Physics or who have recently done so. The analysis was made within the sense making approach which is centered in the user.
Gómez, Nancy-Diana
core  

Investigating the information-seeking behaviour of academic lawyers: from Ellis’s model to design

open access: yes, 2007
Information-seeking is important for lawyers, who have access to many dedicated electronic resources. However there is considerable scope for improving the design of these resources to better support information-seeking. One way of informing design is to
Cox, Anna L.   +6 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Information Seeking Behavior and Needs of Women Parliamentarians of Pakistan: A Case Study [PDF]

open access: yes, 2013
This study probes into the information needs and seeking behavior of women parliamentarians in the 12th National Assembly of Pakistan during 2002 through 2007.
Naqvi, Syeda Bushra Nazli   +2 more
core  

What is the information Seeking and Behavior of Information Seeking?

open access: yes, 2004
Whatever population and using computerized systems in home, Official and receptive dimensions is increasing, whatever digital data is increasing and then searching of users is increasing too. Surely users have problems, Like: Selecting information sources that dont answer to informational needs, disability to specification available facilities in ...
openaire   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Informal Information Sources and Information Seeking Behavior: Investigating the Causes and Factors Affecting Users’ Inclination towards Informal Information Sources

open access: yesIranian Journal of Information Processing & Management, 2009
Research within Library and Information Sciences bespeaks of the significant tendency of (expert and non-expert) users towards informal information sources.
Reza Mokhtarpour
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

From information seeking behavior to knowledge seeking behavior: Analysis of conceptual and theoretical evolution

open access: yesIranian Journal of Information Processing & Management, 2019
Humans do different behaviors to meet their needs constantly. These behaviors are different and each of them constitute subject of disciplines such as psychology, sociology, management, art, knowledge and information science, and some specialized sub ...
Ali Akbari   +2 more
doaj  

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