Results 51 to 60 of about 20,105,587 (307)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

9th International Bielefeld Conference 2009: Upgrading the eLibrary: Enhanced Information Services Driven by Technology and Economics

Liber Quarterly: The Journal of European Research Libraries, 2009
Thisarticle reports on the 9th International Bielefeld Conference ‘Upgrading the eLibrary: Enhanced Information Services Driven by Technology and Economics’, 3-5 February 2009, in Bielefeld, Germany.
Almuth Gastinger
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Other title: Criminal Justice Information Services Training Rules; Other title: Training Rules; Other title: Kansas Highway Patrol CJIS Training; Other title: Kansas Highway Patrol Criminal Justice Information Services Training

, 2006
Caption title.; Date taken from file ...
Kansas Highway Patrol. Criminal Justice Information Services.
core   +1 more source

The use of FinTech products and services by SMEs in an underserved community

South African Journal of Information Management
Background: Financial technology (FinTech), integral to any economy, transcends banking, sparking innovation and accessibility. Its global impact facilitates financial market globalisation.
Tiisetso Phalatse, Joel Arthur, Chris Rensleigh   +2 more
doaj   +1 more source

The Plan for Developing Information Services in Islamic of Azad University [PDF]

تحقیقات کتابداری و اطلاع‌رسانی دانشگاهی, 2008
Purpose: this research is to present a plan to improve Information Services in libraries of Islamic of Azad University, so that more proper services can be presented to the university community through studying the processes.
Dr.Farnosh Azimi Khabbazan
doaj  

Randomized controlled trials in pediatric complementary and alternative medicine: Where can they be found?

BMC Pediatrics, 2003
Background The safety and effectiveness of CAM interventions are of great relevance to pediatric health care providers. The objective of this study is to identify sources of reported randomized controlled trials (RCTs) in the field of pediatric ...
Ajiferuke Isola, Campbell Kaitryn, Sampson Margaret, Moher David   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source