Results 61 to 70 of about 2,772,234 (308)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Navigating information literacy: your information society survival toolkit

open access: yesSouth African Journal of Libraries and Information Science, 2009
The first edition of this work was published in 2006 under the title Navigating information literacy. The change of title and the short gap between editions mark a significant development in the field: from becoming a phenomenon to be explored ...
Peter G. Underwood
doaj   +1 more source

Volume 32 - 2001: GEOSCIENCE INFORMATION : A DYNAMIC ODYSSEY - Proceedings of the 36th Meeting of the Geoscience Information Society [PDF]

open access: yes, 2001
Proceedings of the 36th Meeting of the Geoscience Information Society held November 1-10, 2001 in Boston ...
Geoscience Information Society
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Volume 6 - 1975: RETRIEVAL OF GEOSCIENCE INFORMATION - Proceedings of the 10th Meeting of the Geoscience Information Society [PDF]

open access: yes, 1975
Proceedings of the 10th Meeting of the Geoscience Information Society held October 21, 1975 in Salt Lake City, Utah ...
Geoscience Information Society
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Examining database persistence of ISO/EN 13606 standardized electronic health record extracts: relational vs. NoSQL approaches

open access: yesBMC Medical Informatics and Decision Making, 2017
Background The objective of this research is to compare the relational and non-relational (NoSQL) database systems approaches in order to store, recover, query and persist standardized medical information in the form of ISO/EN 13606 normalized Electronic
Ricardo Sánchez-de-Madariaga   +6 more
doaj   +1 more source

Volume 24 - 1993: FINDING AND COMMUNICATING GEOSCIENCE INFORMATION - Proceedings of the 28th Meeting of the Geoscience Information Society [PDF]

open access: yes, 1993
Proceedings of the 28th Meeting of the Geoscience Information Society held October 25-28, 1993 in Boston ...
Geoscience Information Society
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Information Society and Development

open access: yes, 1997
To harmonize the development process, it is important to provide guidelines for information exchange in developing countries. The national information system of the country should meet the informational and professional needs of researchers, planners, executives, consultants and educational groups.
openaire   +2 more sources

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