Results 71 to 80 of about 7,167,662 (342)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Precipitable Water Vapor Retrieval Based on GNSS Data and Its Application in Extreme Rainfall

Remote Sensing
Water vapor plays a crucial role in maintaining global energy balance and water cycle, and it is closely linked to various meteorological disasters. Precipitable water vapor (PWV), as an indicator of variations in atmospheric water vapor content, has ...
Tian Xian, Ke Su, Jushuo Zhang, Huaquan Hu, Haipeng Wang   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

SDDGRNets: Level–Level Semantically Decomposed Dynamic Graph Reasoning Network for Remote Sensing Semantic Change Detection

Remote Sensing
Semantic change detection technology based on remote sensing data holds significant importance for urban and rural planning decisions and the monitoring of ground objects.
Zhuli Xie, Gang Wan, Yunxia Yin, Guangde Sun, Dongdong Bu   +4 more
doaj   +1 more source

Geometry from Information Geometry

, 2015
We use the method of maximum entropy to model physical space as a curved statistical manifold. It is then natural to use information geometry to explain the geometry of space.
Caticha, Ariel
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Multi-Scale Informer-Based Short-Arc Orbit Determination for Low-Earth-Orbit Satellites

Aerospace
This study addresses the shortcomings of conventional orbital dynamics methods in order to determine initial orbits for short-arc segments of space objects.
Ziwen Zhu, Zhongmin Pei, Hui Chen, Jiameng Wang, Zengying Yue   +4 more
doaj   +1 more source

MINDORO OIL SPILL PROGRESS MONITORING USING SATELLITE IMAGERY [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Oil spills in the sea pose a significant threat to marine and coastal ecosystems including corals, sea grasses, and mangroves. Responding to oil spills in the high seas can be challenging and costly, as it is difficult to survey the area using ships or ...
R. M. de la Cruz, D. C. D. M. Vergara, J. I. A. Tabardillo, A. J. C. Sabuito, N. J. B. Borlongan, K. M. Bantay, R. R. Diwa, A. C. Blanco, A. C. Blanco   +8 more
doaj   +1 more source