Results 71 to 80 of about 68,085 (316)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Saliency for Image Description and Retrieval [PDF]

open access: yes, 2006
We live in a world where we are surrounded by ever increasing numbers of images. More often than not, these images have very little metadata by which they can be indexed and searched.
Hare, Jonathon S., Hare, Jonathon S
core  

A flexible image retrieval framework [PDF]

open access: yes, 2007
This paper discusses a framework for image retrieval. Most current systems are based on a single technique for feature extraction and similarity search. Each technique has its advantages and drawbacks concerning the result quality. Usually they cover one
Lu, Joan   +4 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Evidence‐searching capability among health care professionals: a comparative study

open access: yesBMC Medical Education, 2021
Background Evidence-based practice is among core competencies of health care professionals (HCPs). However, the levels of evidence-searching capability may differ among various disciplines of HCPs as they receive different education and trainings for ...
Szu-Yu Chi   +4 more
doaj   +1 more source

Building simulated queries for known-item topics: an analysis using six european languages [PDF]

open access: yes, 2007
There has been increased interest in the use of simulated queries for evaluation and estimation purposes in Information Retrieval. However, there are still many unaddressed issues regarding their usage and impact on evaluation because their quality, in ...
de Rijke, M.   +6 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Information seeking retrieval, reading and storing behaviour of library users [PDF]

open access: yes, 1997
In the interest of digital libraries, it is advisable that designers be aware of the potential behaviour of the users of such a system. There are two distinct parts under investigation, the interaction between traditional libraries involving the seeking ...
Turner, Kristine
core  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

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