Results 31 to 40 of about 54,463 (250)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Future of Health Information Technology Positions and Professional Qualifications of Employees [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2017
Introduction: The optimal use of information technology in health sector requires due attention to human resources training. The purpose of this study was to determine the future of health information technology positions and professional qualifications ...
Mehrdad Farzandipour, Fatemeh Rangraz Jeddi, Zahra Meidani, Sakineh Sagaeiannejad, Ehsan Nabovati, Mahtab Karami, Maryam Jahanbakhsh, Shahram Tahmasebian, Zohre Mobarak   +8 more
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Large-Scale Video Retrieval via Deep Local Convolutional Features

Advances in Multimedia, 2020
In this paper, we study the challenge of image-to-video retrieval, which uses the query image to search relevant frames from a large collection of videos.
Chen Zhang, Bin Hu, Yucong Suo, Zhiqiang Zou, Yimu Ji   +4 more
doaj   +1 more source

Attribute-Based Encryption Approach for Storage, Sharing and Retrieval of Encrypted Data in the Cloud

IEEE Access, 2020
One of the most cost-effective services in cloud computing is storage, used by businesses and individuals to outsource their massive data to untrusted servers. Efforts have studied problems around this application scenario in different fronts: efficiency,
Miguel Morales-Sandoval, Melissa Hinojosa Cabello, Heidy Marisol Marin-Castro, Jose Luis Gonzalez Compean   +3 more
doaj   +1 more source

CLIP-Based Adaptive Graph Attention Network for Large-Scale Unsupervised Multi-Modal Hashing Retrieval

Sensors, 2023
With the proliferation of multi-modal data generated by various sensors, unsupervised multi-modal hashing retrieval has been extensively studied due to its advantages in storage, retrieval efficiency, and label independence.
Yewen Li, Mingyuan Ge, Mingyong Li, Tiansong Li, Sen Xiang   +4 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The management of information: storage and retrieval of data.

Annali dell'Istituto superiore di sanita, 1995
Internationally harmonized and cost-effective control of chemicals marketed worldwide greatly depend both on the generation of and easy access to reliable and comparable experimental information. Stored data are of use only if information can be retrieved quickly in an understandable form. Some models and theories of information retrieval (e.g.
F, Chiodo, A, Menditto, F, Ouane-Keita, S, Caroli   +3 more
openaire   +1 more source