Results 221 to 230 of about 32,582,800 (335)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Decisional Needs of Young Women (Aged 15-24 Years) in Contraceptive Choice: A Systematic Review. [PDF]

Patient Prefer Adherence
Tu L, Wu H, Dong M, Xiao Y.
europepmc   +1 more source

Gaze information channels in HMD eye tracking: analysis code and derived measures for the GazeBaseVR pilot study

Micaela Martin, Mateu Sbert
openalex   +1 more source

Pregnant women’s perceived understanding and antenatal information needs regarding newborn screening for inherited metabolic diseases in southwestern China: a cross-sectional study [PDF]

Hao Yang, Fenghua He, DAN XIA, Xihong Wang, Hongqian Liu   +4 more
openalex   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Large language models and artificial intelligence for generating, simplifying, and enhancing outpatient clinic letters: A systematic review. [PDF]

PLOS Digit Health
Sheldon R, Wadodkar M, Gan A, Yip R, Zhang Y, Baharani J.   +5 more
europepmc   +1 more source

Compact and interpretable neuro-fuzzy forecasting of photovoltaic power using clear-sky information: a data-screening and benchmarking study for Lomé, Togo

Koudahenou
openalex   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Communicating Risk in the Age of Misinformation: Empirical Frameworks for Understanding Stakeholder Trust. [PDF]

Risk Anal
Weber MS, Lee CM, Kosson DS.
europepmc   +1 more source