Results 191 to 200 of about 45,107,776 (322)

Viewpoint Paper: Some Unintended Consequences of Information Technology in Health Care: The Nature of Patient Care Information System-related Errors

J. Am. Medical Informatics Assoc., 2004
J. Ash, M. Berg, E. Coiera
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Development and Evaluation of an Integrated Nutritional Health Care Information System. [PDF]

Appl Clin Inform
Chen Y, Li M, Xie W, Feng X, Tian H, Wang W.   +5 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A protocol for an assessment of the health information system in Khomas region, Namibia. [PDF]

PLoS One
Jatileni V, Nicol E.
europepmc   +1 more source

FRITZ ZWICKI'S MORPHOLOGICAL APPROACH TO THE DESIGN OF INTEGRATED PROTECTION SYSTEMS FOR INFORMATION AND COMMUNICATION FACILITIES

, 2021
Irina Sergeevna Klimenko
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Architecture, goals and challenges of the Swiss Information System for Antibiotics in Veterinary Medicine (IS ABV). [PDF]

JAC Antimicrob Resist
Schnidrig GA, Schwermer H, Heim D, Léger A, Schüpbach-Regula G.   +4 more
europepmc   +1 more source

A MODEL FOR ENGAGING STUDENTS, COMMUNITIES AND COLLEGES THROUGH THE INTEGRATION OF SERVICE-LEARNING PROJECTS INTO INFORMATION SYSTEMS COURSES

, 2012
Paul Kovacs, Lisa Kovalchick, Gayle Jesse, Thiel, Lisa Kovalchick, L Deneen, A Furco, G Kuh, D Mareck, D Uden, T Larson, M Shephard, R Reinert, M Joseph, G Stone, K Grantham, N Harmancioglu, E Ibrahim, L Mayne, M Glascoff, C Mueller, D Billings, B Peterson, J Yockey, P Larsen, D Twidwell, K Jorgensen, L Preiser-Houy, C Navarrete, R Redman, L Clark, M Rodgers, S Seifer   +32 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source