Results 271 to 280 of about 39,580,984 (375)

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Blockchain in Health Information Systems: A Systematic Review. [PDF]

Int J Environ Res Public Health
Fonsêca ALA, Barbalho IMP, Fernandes F, Arrais Júnior E, Nagem DAP, Cardoso PH, Veras NVR, Farias FLO, Lindquist AR, Dos Santos JPQ, Morais AHF, Henriques J, Lucena M, Valentim RAM.   +13 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Understanding Health Information Systems Utilization Across Public Health Centers in Indonesia: Cross-Sectional Study.

JMIR Med Inform
Aisyah DN, Setiawan AH, Mayadewi CA, Lokopessy AF, Kozlakidis Z, Manikam L.   +5 more
europepmc   +1 more source

Optimal Control of Linear Stochastic Systems With Quadratic Criterion Under Classical Information Structure

, 1976
Kenko Uchida, Etsujiro SHIMEMURA
openalex   +2 more sources

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

The Need and Use of Geographic Information Systems for Environmental Impact Assessment in Nepal

, 1970
Ramesh Prasad Bhatt
openalex   +2 more sources

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source