Results 91 to 100 of about 6,767,647 (299)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

An intelligent LinkNet-34 model with EfficientNetB7 encoder for semantic segmentation of brain tumor

Scientific Reports
A brain tumor is an unnatural expansion of brain cells that can’t be stopped, making it one of the deadliest diseases of the nervous system. The brain tumor segmentation for its earlier diagnosis is a difficult task in the field of medical image analysis.
Adel Sulaiman, Vatsala Anand, Sheifali Gupta, Mana Saleh Al Reshan, Hani Alshahrani, Asadullah Shaikh, M. A. Elmagzoub   +6 more
doaj   +1 more source

Resident research associateships. Postdoctoral and senior research awards: Opportunities for research at the Jet Propulsion Laboratory [PDF]

Opportunities for research as part of NASA-sponsored programs at the JPL cover: Earth and space sciences; systems; telecommunications science and engineering; control and energy conversion; applied mechanics; information systems; and observational ...

core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Thematic insights into the impact of large language models on K-12 education in rural India from student volunteers’ perspectives

Scientific Reports
Artificial Intelligence (AI)–powered tools, particularly Large Language Models (LLMs), are increasingly being explored as catalysts for educational transformation.
Harshita Goyal, Garima Garg, Prisha Mordia, Veena Ramachandran, Dhruv Kumar, Jagat Sesh Challa   +5 more
doaj   +1 more source

Improvement and Validation of NASA/MODIS NRT Global Flood Mapping

Remote Sensing, 2019
The remote-sensing based Flood Crop Loss Assessment Service System (RF-CLASS) is a web service based system developed and managed by the Center for Spatial Information Science and Systems (CSISS).
Li Lin, Liping Di, Junmei Tang, Eugene Yu, Chen Zhang, Md. Shahinoor Rahman, Ranjay Shrestha, Lingjun Kang   +7 more
doaj   +1 more source

What the next decade is going to bring [PDF]

A record of a discussion among a number of the major managers of information systems within the U.S. Government is presented. The topics of discussion focus on assessing the past and present information systems with an emphasis on planning future ...

core   +1 more source

Surveying structural complexity in quantum many-body systems

, 2018
Quantum many-body systems exhibit a rich and diverse range of exotic behaviours, owing to their underlying non-classical structure. These systems present a deep structure beyond those that can be captured by measures of correlation and entanglement alone.
Elliott, Thomas J., Garner, Andrew J. P., Gu, Mile, Mahoney, John R., Suen, Whei Yeap, Thompson, Jayne, Vedral, Vlatko   +6 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source