Results 41 to 50 of about 2,826,368 (216)
Information Technology & psychiatry
Archives of Mental Health, 2010 The advances in the area of Information Technology has a pervasive influence on the society. There is no field where IT cannot help in improving its quality.
K Ashok Reddy
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Information Technology Project
MATEC Web of Conferences, 2016 The author raises the question of suitable use of different software in construction. Currently, there are several design techniques using computer technology. The various stages of the project require their parameters and software settings.
Smirnov Andrei
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Drug, Healthcare and Patient Safety, 2009 Zhengwu LuClinical Research Department, Abbott Vascular, Santa Clara, CA, USAAbstract: Risk assessment during clinical product development needs to be conducted in a thorough and rigorous manner.
Zhengwu Lu
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Technology planning information system [PDF]
مطالعات مدیریت بهبود و تحول, 1995 در این مقاله به ابزارهای مهم برنامه ریزی شامل نمودار میله ای، شبکه و روش مسیر بحرانی پرداخته می شود. نخست چگونگی ایجاد ساختار اجزای کار برای یک پروژه مورد بحث و بررسی قرار می گیرد و سپس هر یک از فنون، هدف های آن، قوانین و رویه های ترسیم هر یک تعریف و ...
ali rezaian
doaj
Cognition and Technology in Education: Knowledge and Information - Language and Discourse
Miscelánea: A Journal of English and American Studies, 2002 Almost from the beginnings of education, technologies in a broad sense have been present, each with its own merits and drawbacks. Computer technology has been hailed with great promise, but early results have been disappointing insofar as computer ...
Robert de Beaugrande
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source