Results 71 to 80 of about 8,942,452 (348)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Developments in information technology, networks and services [PDF]

open access: yes, 2002
A review of policy issues facing Scotland as it faces changing from an industrial society to a knowledge led economy. Identifies the key developments, external trends and internal pressures which library policy makers face.
Law, Derek
core  

Memahami Problema Kebijakan Telemanika

open access: yesJKAP (Jurnal Kebijakan dan Administrasi Publik), 2015
The art changing and development of the information technologies, mainly Internet, have to be responded quickly by Indonesian government bypreparing a set of new policies to reduce its negative impacts.
Ana Nadhya Abrar
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Technology planning information system [PDF]

open access: yesمطالعات مدیریت بهبود و تحول, 1995
در این مقاله به ابزارهای مهم برنامه ریزی شامل نمودار میله ای، شبکه و روش مسیر بحرانی پرداخته می شود. نخست چگونگی ایجاد ساختار اجزای کار برای یک پروژه مورد بحث و بررسی قرار می گیرد و سپس هر یک از فنون، هدف های آن، قوانین و رویه های ترسیم هر یک تعریف و ...
ali rezaian
doaj  

STORYTELLING AS IMPORTANT INFORMATION TECHNOLOGY AND DNA INFORMATION

open access: yesІнтегровані комунікації, 2019
The article explores the methods of informing information and shaping the information environment by means of mass market staging. The study of the components of this tool is especially relevant in today's changing information environment, when the old ...
Tamara Kutsai
doaj   +1 more source

Information technology in ophthalmology [PDF]

open access: yesBritish Journal of Ophthalmology, 1998
Ophthalmology and its adnexal disciplines are in the grip of an explosion in information technology (IT), as are most branches of medicine. Not only do we have a bewildering number of published (on paper that is) periodicals, textbooks, and society (or faculty or college) newsletters to sift, select, and assimilate information from, but we now also ...
openaire   +3 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Perencanaan Information Technology Problem Management Berdasarkan ITIL V3 di Unit IS SSM pada PT TELKOM [PDF]

open access: yes, 2015
Telkom IS SSM (Service Support Management Information System) is a unit of PT Telekomunkasi Indonesian supporters for performing maintenance of telecommunication equipment infrastructure.
Maulana, Y. M. (Yoppy)   +2 more
core  

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