Results 51 to 60 of about 285,379 (265)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

A Model for Evaluating the Impacts of Qualitative Characteristics on the Usefulness of Financial Reporting [PDF]

open access: yesInternational Journal of Management, Accounting and Economics, 2015
The objective of accounting is to provide useful information for the users of financial reporting. The information is considered useful if it possess qualitative characteristics.
Halimeh Rahmani, Hosein Jabari
doaj  

An extension of the technology acceptance model for understanding travelers' adoption of variable message signs.

open access: yesPLoS ONE, 2019
Understanding travelers' acceptance of Advanced Traveler Information Systems (ATIS) is crucial to the implementation of Intelligent Transportation Systems (ITS) capable of mitigating traffic congestion and improving network performance.
El Bachir Diop   +2 more
doaj   +1 more source

SUCCESS DETERMINANTS OF THE REGIONAL GOVERNMENT INFORMATION SYSTEM ON USEFULNESS IN DECISION MAKING OF NTB PROVINCIAL GOVERNMENT [PDF]

open access: yesEurasia: Economics & Business, 2023
The aim of the research is to evaluate whether SIPD can be said to be successful and has a positive impact on usefulness in decision making using the DeLone and McLean Model (2003).
Lodayah Z.M., Akram, Muhsyaf S.A.
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

User’s satisfaction with information system quality: An empirical study on the hospital information systems in Ho Chi Minh City, Vietnam

open access: yesHo Chi Minh City Open University Journal of Science - Economics and Business Administration, 2019
User satisfaction with information system quality has long been a substantial topic in the literature of information system (IS). Based on the key constructs of IS success model (including system quality and information quality) and technology acceptance
Nguyen Tran Thuy Trang, Nguyen Manh Tuan
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

MENILAI KEBERHASILAN SISTEM KEUANGAN DESA (SISKEUDES): VALIDASI MODEL KEBERHASILAN SISTEM INFORMASI DELONE DAN MCLEAN

open access: yesJurnal Riset Akuntansi dan Bisnis Airlangga, 2019
This study aims to test the success Siskeudes by developing a successful model of the DeLone and McLean information systems into seven dimensions. The population was 151 siskeudes operatos in the village goverments Gresik, Nganjuk, Situbondo.
Sigit Kurnianto   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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