Results 61 to 70 of about 149,772 (265)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

INFORMATION WARFARE IN THE NORTH CAUCASUS: FORMS AND MANIFESTATIONS

open access: yesВестник Северо-Кавказского федерального университета, 2022
The article analyzes the forms and manifestations of information warfare in the North Caucasus, examines prevailing in the modern media and the official distinction of citizen journalism, indicated the need to address the issue of citizenship media, the ...
Vladimir Aleksandrovich Romanenko
doaj  

RUSSIAN OFFENSIVE STRATEGY IN THE CONDITIONS OF THE MODERN INFORMATION WARFARE

open access: yesRUDN Journal of Public Administration, 2016
Despite rather volume scientific knowledge of information warfares and methods of their maintaining, the general understanding of information warfare is still not present. And this circumstance does very difficult counteraction to this threat.
Elena S Alexeyeva
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Voting procedures from the perspective of theory of neural networks

open access: yesOpen Engineering, 2016
It is shown that voting procedure in any authority can be treated as Hopfield neural network analogue. It was revealed that weight coefficients of neural network which has discrete outputs −1 and 1 can be replaced by coefficients of a discrete set (−1, 0,
Suleimenov Ibragim   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

ПРЕДПОСЫЛКИ СОЗДАНИЯ КОНЦЕПЦИИ ИНФОРМАЦИОННОЙ ВОЙНЫ В ЭРУ НОВЕЙШИХ ТЕХНОЛОГИЙ

open access: yesSučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2013
Tendencies and prospects of development of the concept of information warfare on the analysis and experience of modern local wars and armed conflicts are considered.
Oleksandr V. Voitko
doaj  

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