Results 31 to 40 of about 891,065 (254)

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego   +10 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Infrastructure Vulnerability Index of drinking water systems to terrorist attacks

open access: yesCogent Engineering, 2018
Drinking water supply systems are vulnerable targets for which counter-terrorism measures have been raised worldwide. The threat of terrorist attacks to these systems has led to the need for the international scientific community to deal with the ...
M. Maiolo, D. Pantusa
doaj   +1 more source

Taxation, Infrastructure, and Endogenous Trade Costs in New Economic Geography [PDF]

open access: yes, 2008
This paper presents a New Economic Geography model with distortionary taxation and endogenized trade costs. Tax revenues finance a public good, infrastructure.
Gruber, Stefan, Marattin, Luigi
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The Influence of Tourist Infrastructure on the Mountain Landscape. Towards a Tourist Landscape. Case Study of the Silesian Beskid

open access: yesEuropean Countryside, 2020
The dynamic development of tourist infrastructure can damage the value of a landscape. Thus, the identification of the impact of tourist infrastructure on landscape is an important issue in the context of the limitation of further degradation of ...
Żemła-Siesicka Anna
doaj   +1 more source

Quality Index Approach for Analysis of Urban Green Infrastructure in Himalayan Cities

open access: yesLand, 2023
In fast urbanizing cities, fragmentation of urban green infrastructure (UGI) commonly arises due to lack of efficient planning to maintain the quantity and improve their quality.
Mangalasseril Mohammad Anees   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Scientific methodological approach to defining projected indicator of financial market infrastructural efficiency [PDF]

open access: yes, 2017
This research article proposes a scientific methodological approach to calculation of financial market infrastructure index that characterizes a level of infrastructural efficiency. It also describes a staged algorithm of its calculation.
Rekunenko, Ihor Ivanovych   +2 more
core   +1 more source

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