Results 51 to 60 of about 4,917,525 (294)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
The Influence of Government Expenditure on the Human Development Index in NTT Province
JIET (Jurnal Ilmu Ekonomi Terapan)Researchers analyzed government spending on health, education, and infrastructure in influencing the human development index in NTT Province. The research data is panel data in 22 districts/cities, namely health, education, and infrastructure expenditure
Marianus Antonius Deo Datus Banase +1 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
, 2021 This report highlights the challenges the infrastructure sector faces in addressing the UK’s net-zero carbon commitment by 2050. Included is a manifesto for change, which will enable the infrastructure sector to measure, control and reduce carbon ...
Net Zero Infrastructure Industry Coalition
core +1 more source
Victoria's draft 30-year infrastructure strategy
, 2016 Infrastructure Victoria is undertaking the first ever thirty year infrastructure strategy for Victoria. The community and stakeholders are active participants in the development of this strategy through consultation and engagement.
Infrastructure Victoria
core +1 more source
Infrastructure and economic growth in ECOWAS member states: The Westerlund co-integration approach
Jurnal Perspektif Pembiayaan dan Pembangunan DaerahThis research explores the impact of infrastructure on member states' economic growth in the Economic Community of West African States (ECOWAS). Utilizing panel secondary data sourced from the World Bank Development Indicators (WDI) and the African ...
Fadila Kabir Usman +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
European Countryside, 2020 The dynamic development of tourist infrastructure can damage the value of a landscape. Thus, the identification of the impact of tourist infrastructure on landscape is an important issue in the context of the limitation of further degradation of ...
Żemła-Siesicka Anna
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source