Results 71 to 80 of about 165,534 (345)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Short- and long-term complications of insulin pump therapy in children and adolescents with type 1 diabetes: a multicenter cross-sectional study from Saudi Arabia

Therapeutic Advances in Chronic Disease
Background: Insulin pump therapy improves glycemic control in children with type 1 diabetes but is associated with technical and dermatological complications that can impact adherence. Research on these adverse effects in pediatric populations is limited.
Ayman Bakkar, Enad Althobaiti, Ibtisam Alqahtani, Lujain A Abualkhair, Naglaa M Kamal, Mohammed Althobaiti, Turki Alotaibi, Lura Habib, Lujain Alharthi, Saad Aljuaid, Maha Althuwaybi, Haneen Alshehri, Muhannad Alotaibi, Wael Kamal, Mutlaq Aljuaid, Samia Almalki, Abdulaziz Alsaedi   +16 more
doaj   +1 more source

Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery [PDF]

, 2008
Objectives: In addition to blood-sparing effects, aprotinin may have cardioprotective and anti-inflammatory effects during cardiopulmonary bypass-assisted cardiac surgery.
Bert, C., Ceuppens, J., De Buck, F., Delforge, M., Kasran, A., Meyns, B., Sergeant, P., Van Duppen, V., Van Hemelrijck, J., Wouters, Patrick   +9 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The cardioprotective effect of intralipid in decreasing the ischemic insults during off-pump coronary artery revascularization

Ain Shams Journal of Anesthesiology, 2021
Background Off pump coronary artery revascularization (OPCAB) surgeries have benefits over the conventional on pump cardiac surgery, because it avoids the trauma caused by cardiopulmonary bypass (CPB) and minimize aortic manipulation.
Maha Sadek El Derh, Samar Mohamed Abdel Twab, Mohamed Elgouhary   +2 more
doaj   +1 more source

In-line filter included into the syringe infusion pump assembly reduces flow irregularities [PDF]

, 2018
Purpose: To evaluate whether an in-line filter inserted in the syringe pump infusion line assembly influences start-up times and flow irregularities during vertical pump displacement at low infusion rates. Methods: Fluid delivery after syringe pump start-
Bernet, V., Brotschi, B., Doell, C., Grass, B., Weiss, M.   +4 more
core  

Use of apomorphine in Parkinsonian patients with neuropsychiatric complications to oral treatment [PDF]

, 1997
Neuropsychiatric side effects often complicate anti-Parkinsonian therapy and pose a significant problem in the optimal management of idiopathic Parkinson's disease.
Abbott, R.J., Chaudhuri, K.R., Ellis, C, Leigh, P.N., Lemmens, Gilbert, Parkes, J.D., Pye, I.F.   +6 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A preliminary assessment of vital-signs-integrated patient-assisted intravenous opioid analgesia (VPIA) for postsurgical pain

BMC Anesthesiology, 2020
Background We developed a Vital-signs-integrated Patient-assisted Intravenous opioid Analgesia (VPIA) analgesic infusion pump, a closed-loop vital signs monitoring and drug delivery system which embodied in a novel algorithm that took into account ...
Ban Leong Sng, Daryl Jian’an Tan, Chin Wen Tan, Nian-Lin Reena Han, Rehena Sultana, Alex Tiong Heng Sia   +5 more
doaj   +1 more source

Insulin pump therapy in transient neonatal diabetes mellitus [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2013
Neonatal diabetes mellitus (NDM) is a rare disease requiring insulin treatment. Its treatment is primarily focused on maintaining adequate glycemic control and avoiding hypoglycemia.
Joong Heum Park, Jeong Hee Kang, Kyu-Hyung Lee, Nam-Hyo Kim, Han-Wook Yoo, Dae-Yeol Lee, Eun-Gyong Yoo   +6 more
doaj   +1 more source