Results 61 to 70 of about 1,401,074 (300)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Experience on the Use of Subcutaneous Placement of Complete Embedding Infusion Pump in Intraabdominal Chemotherapy

Huli yanjiu, 1997
Subcutaneous placement of complete embedding infusion pump were used in 286 chemotherapy patients with Gastrointestinal carcinoma.There were 451 pumps.Infection developed in 32 cases in them,pump inclination occurred in 56 cases and catheter obstruction ...
李金华
doaj  

Short- and long-term complications of insulin pump therapy in children and adolescents with type 1 diabetes: a multicenter cross-sectional study from Saudi Arabia

Therapeutic Advances in Chronic Disease
Background: Insulin pump therapy improves glycemic control in children with type 1 diabetes but is associated with technical and dermatological complications that can impact adherence. Research on these adverse effects in pediatric populations is limited.
Ayman Bakkar, Enad Althobaiti, Ibtisam Alqahtani, Lujain A Abualkhair, Naglaa M Kamal, Mohammed Althobaiti, Turki Alotaibi, Lura Habib, Lujain Alharthi, Saad Aljuaid, Maha Althuwaybi, Haneen Alshehri, Muhannad Alotaibi, Wael Kamal, Mutlaq Aljuaid, Samia Almalki, Abdulaziz Alsaedi   +16 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

INFUSION PUMP SURGERY: ACHIEVEMENTS AND LIMITATION

The Iraqi Journal of Medical Sciences, 2016
Background:Infusion pump is a special pump machine, with two different types, programmable and fixed flow pumps. These pumps used for administration of drugs through lumbar intrathecal route.
Yasir MH. Hamandi, Abdulameer J. Al-Khafaji, Haider A. Al-Atbee   +2 more
doaj   +4 more sources

Iloprost infusion by a new device as a portable syringe pump: safety, tolerability and agreement

Italian Journal of Medicine, 2012
Background Iloprost, prostacyclin (PGI2) analogue, effective in treatment of peripheral arterial disease, secondary Raynaud's phenomenon (RP) to connective tissue disease (CTD), vasculitis, pulmonary hypertension, is usually infused through peristaltic ...
Paola Faggioli, Alba Sciascera, Leopoldo Giani, Antonino Mazzone   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Efficacy evaluation of syringe pump developed for continuous drug infusion

Journal of dental anesthesia and pain medicine, 2016
Background In dental intravenous sedation, continuous intravenous infusion of a low-dose drug requires an infusion pump such as a syringe pump. To develop a new syringe pump for clinical use, the functions of the pump must meet certain international ...
Bongsu Jung, K. Seo, Suk Jin Kwon, Kiyoung Lee, Su Hong, H. Seo, G. Kim, Geun-Mook Park, Juhee Jeong, Soowon Seo   +9 more
semanticscholar   +1 more source

Gravity versus pump-driven infusion in targeted radionuclide therapy: a model-based dosimetric evaluation of extravasation

EJNMMI Physics
Background Intravenous administration of $$^{177}$$ Lu-labeled radiopharmaceuticals (RPMs) such as PSMA and DOTATATE entails a risk of extravasation, potentially resulting in absorbed doses exceeding thresholds for deterministic tissue damage.
Olivia Lienhardt, Oreste Allegrini, Nathan Poterszman, Florian Ritzenthaler, Clémence Porot, Christophe Mazzara, Francois Somme, Julien Salvadori   +7 more
doaj   +1 more source