Results 41 to 50 of about 5,157 (281)

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Effectiveness evaluation of an integrated automatic termomechanic massage system (SMATH system) in non-specific sub-acute and chronic low back pain - a randomized double-blinded controlled trial, comparing SMATH therapy versus sham therapy: study protocol for a randomized controlled trial [PDF]

, 2011
Background Low back pain (LBP) is a major health problem in modern society, with 70-85% of the population experiencing LBP at some time in their lives. Each year, 5-10% of the workforce misses work due to LBP, most for less than 7 days. Almost 10% of all
Mazzolari Rita, La Scala Elide, Fasoli Paola, Busè Gabriella, Bosoni Roberto, Buselli Paolo, Zanetti Federica, Messina Sara   +7 more
core   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Artifact‐Minimizing Ultrathin Transparent Electrodes Fabricated via iCVD for In Vivo Optogenetic Stimulation and Neural Signal Monitoring of Primary Visual Cortex

Advanced Functional Materials, EarlyView.
We present ultrathin flexible transparent electrodes through iCVD‐enabled molecular control of 10 nm gold films on poly(dimethylaminomethylstyrene). In vivo validation demonstrated photoelectric artifact reduction vs. opaque electrodes and preservation of natural neural dynamics.
Tae Jin Mun, Minju Kim, Chaesung Kim, Yunyoung Choi, In‐Yeop Baek, Younghak Cho, Gyeongyong Lee, Yerim Jang, Min‐Ho Nam, Wonryung Lee, Maesoon Im, Hyejeong Seong   +11 more
wiley   +1 more source

Unlocking norepinephrine potential innovations in formulation and smart systems

Discover Pharmaceutical Sciences
Norepinephrine (NE), a critical neurotransmitter and hormone, profoundly influences cardiovascular function and stress response. However, inherent pharmacokinetic challenges, notably rapid enzymatic degradation and a short half-life, mandate continuous ...
Samarth Kumar, Sachin N. Sanap, Milan Vasoya, Prachi Pandey, Ajay Khopade, Krutika K. Sawant   +5 more
doaj   +1 more source

Focal, remote-controlled, chronic chemical modulation of brain microstructures [PDF]

, 2019
Direct delivery of fluid to brain parenchyma is critical in both research and clinical settings. This is usually accomplished through acutely inserted cannulas.
Cima, Michael J., Cotler, Max Joseph, Dagdeviren, Canan, Graybiel, Ann M, Joe, Pauline, Langer, Robert S, Nunez Lopez, Carlos, Ramadi, Khalil, Rousseau, Erin Byrne, Spencer, Kevin C   +9 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Clinical observation of the effect of a totally implantable programmable device for continuous intrathecal infusion in the treatment of intractable neuropathic pain

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
Objective To observe the curative effect and life quality improvement in patients with intractable neuropathic pain (NP) after implanting a programmable continuous intrathecal infusion pump.
Yang YANG, Ke-qin YANG, Bi-fa FAN
doaj  

Implantable Infusion Pump Management of Insulin Resistant Diabetes Mellitus

Annals of Surgery, 1985
Diabetes mellitus with resistance to insulin administered subcutaneously or intramuscularly (DRIASM) is a rare and brittle form of Type I diabetes, found predominantly in young females and characterized by inadequate glycemic response to subcutaneous or intramuscular insulin administration.
H, Buchwald, E P, Chute, F J, Goldenberg, C R, Hitchcock, B J, Hoogwerf, J J, Barbosa, W M, Rupp, T D, Rohde   +7 more
openaire   +3 more sources