Results 21 to 30 of about 5,157 (281)

Intrastriatal Memantine Infusion Dampens Levodopa-Induced Dyskinesia and Motor Deficits in a Mouse Model of Hemiparkinsonism

open access: yesFrontiers in Neurology, 2019
Although the administration of dopamine precursor levodopa remains as the mainstay for the treatment of Parkinson's disease, long-term exposure to levodopa often causes a disabling complication, referred to as levodopa-induced dyskinesias. Therefore, the
Masatoshi Ogawa   +9 more
doaj   +1 more source

Plain radiography in patients treated with intrathecal drug delivery using an implantable pump device

open access: yesInsights into Imaging, 2017
Objectives Intrathecal drug administration using an implanted pump system is well established in intractable spasticity and pain. However, despite continuous advancements in manufacturing technology, adverse events related to the pump and catheter still ...
Elmar M. Delhaas   +4 more
doaj   +1 more source

The Internet of Hackable Things [PDF]

open access: yes, 2017
The Internet of Things makes possible to connect each everyday object to the Internet, making computing pervasive like never before. From a security and privacy perspective, this tsunami of connectivity represents a disaster, which makes each object ...
Dragoni, Nicola   +2 more
core   +2 more sources

Genomic stratification beyond Ras/B‐Raf in colorectal liver metastasis patients treated with hepatic arterial infusion

open access: yesCancer Medicine, 2019
Background Resection of colorectal liver metastases (CLM) can cure disease, but many patients with extensive disease cannot be fully resected and others recur following surgery.
J. Joshua Smith   +19 more
doaj   +1 more source

Intravenous treprostinil via an implantable pump in pediatric pulmonary arterial hypertension

open access: yesPulmonary Circulation, 2018
Intravenous prostacyclin-based therapy improves survival in children with pulmonary arterial hypertension (PAH), but is typically administered via an external infusion pump, which places a considerable burden on the patient.
Susanna Desole   +3 more
doaj   +1 more source

Intrathecal Baclofen Infusion Pumps in the Treatment of Spasticity: A Retrospective Cohort Study in a Portuguese Centre

open access: yesActa Médica Portuguesa, 2019
Introduction: Spasticity is a complex problem in patients with neurological disorders and may distress their quality of life. Intrathecal baclofen infusion pumps reduce spasticity with low doses and minimal side effects but are not free from ...
Pedro Videira Reis   +5 more
doaj   +1 more source

The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice [PDF]

open access: yes, 2018
BACKGROUND: The orphan receptor G protein–coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
Divorty, Nina   +3 more
core   +1 more source

Safety of Active Implantable Devices during MRI Examinations: A Finite Element Analysis of an Implantable Pump [PDF]

open access: yes, 2007
The goal of this study was to propose a general numerical analysis methodology to evaluate the magnetic resonance imaging (MRI)-safety of active implants.
Burger, Jürgen   +7 more
core   +1 more source

Closed-loop insulin delivery for treatment of type 1 diabetes [PDF]

open access: yes, 2011
Type 1 diabetes is one of the most common endocrine problems in childhood and adolescence, and remains a serious chronic disorder with increased morbidity and mortality, and reduced quality of life.
Daniela Elleri   +2 more
core   +3 more sources

Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats[S]

open access: yesJournal of Lipid Research, 2017
Nicotinic acid (NiAc) is a potent inhibitor of lipolysis, acutely reducing plasma free fatty acid (FFA) concentrations. However, a major FFA rebound is seen during rapid NiAc washout, and sustained exposure is associated with tolerance development, with ...
Tobias Kroon   +4 more
doaj   +1 more source

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