Results 11 to 20 of about 2,338 (236)

Genomic stratification beyond Ras/B‐Raf in colorectal liver metastasis patients treated with hepatic arterial infusion

Cancer Medicine, 2019
Background Resection of colorectal liver metastases (CLM) can cure disease, but many patients with extensive disease cannot be fully resected and others recur following surgery.
J. Joshua Smith, Walid K. Chatila, Francisco Sanchez‐Vega, Jashodeep Datta, Louise C. Connell, Bryan C. Szeglin, Azfar Basunia, Taryn M. Boucher, Haley Hauser, Isaac Wasserman, Chao Wu, Andrea Cercek, Jaclyn F. Hechtman, Chris Madden, William R. Jarnagin, Julio Garcia‐Aguilar, Michael I. D'Angelica, Rona Yaeger, Nikolaus Schultz, Nancy E. Kemeny   +19 more
doaj   +1 more source

Intravenous treprostinil via an implantable pump in pediatric pulmonary arterial hypertension

Pulmonary Circulation, 2018
Intravenous prostacyclin-based therapy improves survival in children with pulmonary arterial hypertension (PAH), but is typically administered via an external infusion pump, which places a considerable burden on the patient.
Susanna Desole, Manuel Jonas Richter, Alexander Heine, Ralf Ewert   +3 more
doaj   +1 more source

Intrathecal Baclofen Infusion Pumps in the Treatment of Spasticity: A Retrospective Cohort Study in a Portuguese Centre

Acta Médica Portuguesa, 2019
Introduction: Spasticity is a complex problem in patients with neurological disorders and may distress their quality of life. Intrathecal baclofen infusion pumps reduce spasticity with low doses and minimal side effects but are not free from ...
Pedro Videira Reis, Catarina Rocha Vieira, Ana Cristina Midões, Virginia Rebelo, Paula Barbosa, Armanda Gomes   +5 more
doaj   +1 more source

Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats[S]

Journal of Lipid Research, 2017
Nicotinic acid (NiAc) is a potent inhibitor of lipolysis, acutely reducing plasma free fatty acid (FFA) concentrations. However, a major FFA rebound is seen during rapid NiAc washout, and sustained exposure is associated with tolerance development, with ...
Tobias Kroon, Tania Baccega, Arne Olsén, Johan Gabrielsson, Nicholas D. Oakes   +4 more
doaj   +1 more source

Alívio da dor crônica não neoplásica com opiáceos Alivio del dolor cronico no neoplásico con opiáceos Non oncologic chronic pain relief with opioids

Revista Latino-Americana de Enfermagem, 1999
O uso de opiáceos para o controle da dor crônica não relacionada ao câncer é controverso. Avaliar o alívio da dor e as mudanças nas atividades de vida diária advindas da infusão intratecal de opiáceos em 11 doentes, com dor crônica não neoplásica, foram ...
Cibele Andrucioli de Mattos Pimenta, Manoel Jacobsen Teixeira, Cláudio Fernandes Correa, Fabiana S. Müller, Fabrícia C.G Goes, Raphael M Marcon   +5 more
doaj   +1 more source

Evaluation of the safety of users of active implantable medical devices (AIMD) in the working environment in terms of exposure to electromagnetic fields – Practical approach to the requirements of European Directive 2013/35/EU

International Journal of Occupational Medicine and Environmental Health, 2018
Objectives Electromagnetic fields (EMF) may cause malfunctions in electronic devices, in particular in active implantable medical devices (AIMD), along with discomfort or health hazards to users.
Patryk Zradziński, Jolanta Karpowicz, Krzysztof Gryz, Wiesław Leszko   +3 more
doaj   +1 more source

Complications of continuous intraperitoneal insulin infusion with an implantable pump

World Journal of Diabetes, 2012
To monitor the course of continuous intraperitoneal insulin infusion (CIPII) and to gain more insight into possible complications.A retrospective, longitudinal observational cohort study in patients with type 1 diabetes mellitus (T1DM) was performed. Only patients with "brittle" T1DM who started CIPII between January 1, 2000 and June 1, 2011, and were ...
van Dijk, Peter R, Logtenberg, Susan J. J., Groenier, Klaas H, Haveman, Jan Willem, Kleefstra, Nanno, Bilo, Henk J. G.   +5 more
openaire   +3 more sources

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Multimodal Soft Surgical Robots Enabled by Eco‐Degradable, Sterilizable Polymers and Transient Electronics

Advanced Functional Materials, EarlyView.
A compostable PGS soft surgical robot with interchangeable modules integrates transient Mo tactile and Si thermal sensors for dual feedback. The device preserves its function after clinical‐grade sterilization, demonstrates stable actuation and cardiac tissue grasping with real‐time in vivo pulsatile monitoring, and biodegrades post‐use with soil‐safe, 
Minseong Chae, Kyung‐Sub Kim, Gyeong‐Seok Hwang, Jun‐Seok Shim, Sung‐Woo Kim, Yong‐Wu Kim, Jieun Han, Jae‐Young Bae, Jae‐Hwan Lee, Minjung Chae, Jooik Jeon, Joo‐Hyeon Park, You‐Jung Park, Ju‐Yong Lee, Sung‐Geun Choi, Min‐Ha Oh, Yong‐Joong Shin, Young‐In Ryu, Ji‐Woo Gu, Seong‐Yu Choi, Jeong‐Yun Sun, Jung Keun Hyun, Myoung‐Ryul Ok, Sang Yup Kim, Edyta Wyszkowska, Ju‐Young Kim, Kang‐Sik Lee, Seung‐Kyun Kang   +27 more
wiley   +1 more source

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source