Results 201 to 210 of about 63,253 (224)

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo   +10 more
wiley   +1 more source

Biomedical Applications of Gadolinium‐Containing Biomaterials: Not Only MRI Contrast Agent

open access: yesAdvanced Science, EarlyView.
This paper summarizes the latest applications and potential mechanisms of the rare earth element gadolinium in biomedical fields, in addition to its traditional application as an MRI contrast agent, including osteogenesis, antimicrobial, antitumor, bioimaging, bioprobes, and so on.
Xingtong Pan   +9 more
wiley   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

open access: yesAdvanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang   +13 more
wiley   +1 more source

The Results of ADVANCE-CIDP IVIG Trial: Intravenous Immunoglobulin 10% Therapy With GAMMAGARD LIQUID/Kiovig for Treatment of Relapse in Chronic Inflammatory Demyelinating Polyradiculoneuropathy. [PDF]

open access: yesEur J Neurol
Pasnoor M   +22 more
europepmc   +1 more source

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee   +5 more
wiley   +1 more source

Low‐Coordination Configuration Single‐Atom Manganese Nanozymes for NIR‐Imaging‐Oriented Efficient Catalytic Oncotherapy

open access: yesAdvanced Science, EarlyView.
The manuscript designs a type of SA Mn‐CDs with low coordination Mn‐N2 configuration hydrothermally synthesized by chelating manganese atoms with ethylenediamine tetraacetic acid. SA Mn‐CDs not only have more active sites at the atomic level for high efficiently peroxidase‐like activity but also show excellent fluorescent ability at the cellular and ...
Peiwei Jin   +8 more
wiley   +1 more source

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