Results 71 to 80 of about 105,877 (293)

Propofol and children--what we know and what we do not know. [PDF]

, 2011
The pharmacokinetics of propofol are relatively well described in the pediatric population. Recent work has confirmed the validity of allometric scaling for predicting propofol disposition across different species and for describing pediatric ontogenesis.
Rigby-Jones, AE, Sneyd, JR
core   +2 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Understanding safety differently: developing a model of resilience in the use of intravenous insulin infusions in hospital in-patients—a feasibility study protocol

BMJ Open, 2019
Background Intravenous insulin infusions are considered the treatment of choice for critically ill patients and non-critically ill patients with persistent raised blood glucose who are unable to eat, to achieve optimal blood glucose levels.
Rick Iedema, Mais Hasan Iflaifel, Rosemary Lim, Kath Ryan, Clare Crowley   +4 more
doaj   +1 more source

Inclusion body myositis: therapeutic approaches. [PDF]

, 2012
The idiopathic inflammatory myopathies are a heterogeneous group of diseases that include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and other less common myopathies.
Aggarwal, Rohit, Oddis, Chester V
core   +1 more source

Extracorporeal Catalytic Hemoperfusion Therapy for Refractory Septic Shock Using Ceria Nanoparticle‐Embedded Porous Microbeads

Advanced Functional Materials, EarlyView.
This study introduces an extracorporeal hemoperfusion system incorporating porous microbeads embedded with autocatalytic ceria nanoparticles (CeNPs) for targeted reactive oxygen species (ROS) scavenging in septic shock. The blood‐compatible hemoperfusion cartridge demonstrated significant improvements in survival, hemodynamic stability, and organ ...
Pilseon Im, Han‐Gil Jeong, Donghee Kim, Jimin Song, Ngoc Man Phan, Eun‐seo Choi, Young‐Min Kim, Seo‐Hyeon Jeong, Jooho Park, Inwon Park, Jaeyun Kim   +10 more
wiley   +1 more source

Accelerated Infliximab Infusion: Safety, Factors Predicting Adverse Events, Patients' Satisfaction and Cost Analysis. A Cohort Study in IBD Patients. [PDF]

PLoS ONE, 2016
Standard Infliximab infusion consists of a 2-hour intravenous administration. Recently, Infliximab shortened infusion has been included in the Infliximab label as possible maintenance regimen for patients tolerating Infliximab induction therapy.To verify
S Mazzuoli, D Tricarico, F Demma, G Furneri, F W Guglielmi   +4 more
doaj   +1 more source

Deletion of the GABAA α2-subunit does not alter self dministration of cocaine or reinstatement of cocaine seeking [PDF]

, 2014
Rationale GABAA receptors containing α2-subunits are highly represented in brain areas that are involved in motivation and reward, and have been associated with addiction to several drugs, including cocaine.
A Agrawal, AC Barrett, B. Halbout, C Schwarzer, C. I. Dixon, CI Dixon, CI Dixon, CI Dixon, D. N. Stephens, DM Dick, DM Thompson, EM Weerts, G Brown, HC Fox, HJ Edenberg, HN Katz, HV Morris, HV Morris, J Covault, J Merrer Le, JD Salamone, JR Taylor, K Low, KL Conrad, LA Knackstedt, LJ Herberg, LM Reynolds, LO Bauer, M Filip, M Filip, MA Enoch, MA Enoch, MJ Thomas, ND Volkow, P Waelti, PA Broderick, PA Lind, R Keiflin, R Sinha, RA Wise, RW Keller Jr, S Erb, S Pirker, S Taverna, S Villafuerte, S. L. King, SA Kushner, SH Ahmed, SL Dewey, SS Negus, TE Robinson, TW Robbins, TW Robbins, TW Robbins, W Schultz, Y Kawaguchi   +55 more
core   +1 more source

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Pilot Safety Evaluation of Varenicline for the Treatment of Methamphetamine Dependence. [PDF]

, 2009
Despite the worldwide extent of methamphetamine dependence, no medication has been shown to effectively treat afflicted individuals. One relatively unexplored approach is modulation of cholinergic system function.
Clement, Clayton, De La Garza, Richard, London, Edythe D, Miotto, Karen, Newton, Thomas F, Sevak, Rajkumar J, Shoptaw, Steven, Swanson, Aimee-Noelle, Zorick, Todd   +8 more
core  

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia. [PDF]

, 2016
Acute myeloid leukemia (AML) cells meet the higher energy, metabolic, and signaling demands of the cell by increasing mitochondrial biogenesis and mitochondrial protein translation.
Brandwein, Joseph, Douer, Dan, Gronda, Marcela, Gupta, Vikas, Hurren, Rose, Jitkova, Yulia, Kambhampati, Suman, Minden, Mark D, Reed, Gregory A, Schiller, Gary J, Schimmer, Aaron D, Schuh, Andre C, Shamas-Din, Aisha, Tallman, Martin S, Yee, Karen W   +14 more
core   +1 more source