Results 81 to 90 of about 294,710 (302)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial [PDF]

, 2009
<p><b>Background and Purpose:</b>Although magnesium is neuroprotective in animal stroke models, no clinical benefit was confirmed in the Intravenous Magnesium Efficacy in Stroke (IMAGES) trial of acute stroke patients.
Alger, J.R., Lees, K.R., Saver, J.L., Weir, C.J., Starkman, S., Muir, K.W., Davis, S.M., Kidwell, C.S., Chen, C., De Silva, D.A.   +9 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Symptomatic severe hypophosphatemia after intravenous ferric carboxymaltose

JGH Open, 2019
Intravenous iron is commonly prescribed for treatment of iron deficiency, with modern formulations demonstrating an acceptable safety profile in the majority of patients.
Wendy Fang, Lawrence P McMahon, Stephen Bloom, Mayur Garg   +3 more
doaj   +1 more source

Estudo prospectivo, randomizado e controlado sobre o tempo de permanência de cateteres venosos periféricos em crianças, segundo três tipos de curativos Estudio prospectivo, aleatorio y controlado sobre el período de permanencia de catéteres venosos periféricos insertados en niños, según tres tipos de cura Prospective, randomized and controlled trial on the dwell time of peripheral intravenous catheters in children, according to three dressing regimens

Revista Latino-Americana de Enfermagem, 2005
Estudo prospectivo, randomizado e controlado, que verificou a influência de três tipos de curativos, sobre o tempo de permanência de cateteres venosos periféricos (CVP) em crianças. Os grupos de estudo foram compostos por curativos com gaze estéril (GE 1)
Ariane Ferreira Machado, Mavilde L. G. Pedreira, Massae Noda Chaud   +2 more
doaj   +1 more source

Enhanced accuracy in gravity-based intravenous infusion using pulse oximeter drop counting and measured single-drop weights [PDF]

Anesthesia and Pain Medicine
Background Intravenous (IV) fluid therapy is essential and widely used; however, it is associated with high error rates, largely due to human factors, necessitating constant and careful monitoring by medical staff.
Daeseok Oh, Myoung Jin Ko, Jae Hwan Kim, Yeiheum Park, Sungho Moon   +4 more
doaj   +1 more source

Intravenous infusions of nutrients and sleep in the rat: an ischymetric sleep regulation hypothesis

, 1980
Unrestrained food-deprived rats received their daily caloric needs through continuous or discontinuous intravenous infusions of specific nutritive substances over a period of 3 consecutive days each, and the effect on sleep monitored by ...
J. Danguir, S. Nicolaidis
core   +1 more source

Intravenous ATP infusions can be safely administered in the home setting: a study in pre-terminal cancer patients [PDF]

, 2007
The aim of the study was to investigate the safety of adenosine 5'-triphosphate (ATP) administration at home in pre-terminal cancer patients. Included were patients with cancer for whom medical treatment options were restricted to supportive care, who ...
Pieter C. Dagnelie, van den Borne, B.E., van Henten, A.M., Pierre S. Hupperets, Marten R. Nijziel, Nijziel, M.R., Gielisse, E.A., Marieke van den Beuken-van Everdingen, Sandra Beijer, Ben E. E. M. van den Borne, van den Beuken-van Everdingen, M.H.J., Hupperets, P.S.G.J., Beijer, S., Arjen M. J. van Henten, Dagnelie, P.C., Eric A. R. Gielisse   +15 more
core   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source