Strategies to mitigate bias from time recording errors in pharmacokinetic studies [PDF]
arXiv, 2023 Opportunistic pharmacokinetic (PK) studies have sparse and imbalanced clinical measurement data, and the impact of sample time errors is an important concern when seeking accurate estimates of treatment response. We evaluated an approximate Bayesian model for individualized pharmacokinetics in the presence of time recording errors (TREs), considering ...
arxiv
Pregnancy Complicated by Gorham–Stout Disease and Refractory Chylothorax
American Journal of Perinatology Reports, 2016 Introduction Gorham–Stout Disease (GSD) is a rare disorder of bony destruction due to lymphangiomatosis, and is often triggered by hormones. One complication of GSD is the development of chylothorax, which carries a high mortality rate.
Jessica Hellyer +7 more
doaj +1 more source
Sounding the metabolic orchestra: A delay dynamical systems perspective on the glucose-insulin regulatory response to on-off glucose infusion [PDF]
arXiv, 2023 We investigate the consequences of periodic, on-off glucose infusion on the glucose-insulin regulatory system on the basis of a system-level mathematical model with two explicit time delays. Studying the effects of such infusion protocols is mathematically challenging yet a promising direction for probing the system response to infusion. We pay special
arxiv
Experience and Evidence are the eyes of an excellent summarizer! Towards Knowledge Infused Multi-modal Clinical Conversation Summarization [PDF]
, 2023 With the advancement of telemedicine, both researchers and medical practitioners are working hand-in-hand to develop various techniques to automate various medical operations, such as diagnosis report generation. In this paper, we first present a multi-modal clinical conversation summary generation task that takes a clinician-patient interaction (both ...
arxiv +1 more source
Nutrition in Clinical Practice, Volume 38, Issue 1, Page 129-137, February 2023., 2023 Abstract Background Chronic analgesic use is described in home parenteral nutrition (HPN)–dependent patients, but there are limited data on factors associated with opioid use for noncancerous pain. Methods Patients attending a national UK intestinal failure reference center were divided in two groups according to strong opioid (SO) usage; risk factors ...
Liat Deutsch +7 more
wiley +1 more source
The related factors of phlebitis among low birth weight infants in perinatology ward
Pediatric Reports, 2020 Peripheral intravenous line placement might lead to some risks and complications in low birth weight (LBW) infants including phlebitis, which shows varying percentages. This study aimed to analyze the causative factors of phlebitis among LBW infants in a
Risna Yuningsih +2 more
doaj +1 more source
Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modeling [PDF]
arXiv, 2023 Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion over multiple hours. Several studies hypothesize that the latter better represents the prolonged and pronounced inflammation observed in conditions like sepsis.
arxiv
Paraneoplastic Hypoglycemia Leading to Insulin Independence in a Patient With Type 1 Diabetes
AACE Clinical Case Reports, 2021 Objective: Non–islet cell tumor hypoglycemia (NICTH) is an uncommon paraneoplastic syndrome associated with mesenchymal neoplasms such as gastrointestinal stromal tumors (GISTs).
Nami Safai Haeri, MD +2 more
doaj
Hypersensitivity reactions to high osmolality Total Parenteral Nutrition: a case report
Allergy, Asthma & Clinical Immunology, 2019 Background The full range of allergic reactions to Total Parenteral Nutrition (TPN) remains unknown. Additionally, beyond individual allergens, there may be other factors contributing to TPN hypersensitivity reactions. Case presentation We present a case
Steph A. Pang +4 more
doaj +1 more source
Management of anemia in inflammatory bowel disease: a challenge in everyday clinical practice
Gastroenterology Review, 2017 Anemia is the most common extraintestinal manifestation and complication of inflammatory bowel disease (IBD). Its etiology is multifactorial and mostly is a combination of iron deficiency anemia (IDA) and chronic anemia (ACD).
Edyta Tulewicz-Marti +2 more
doaj +1 more source