Results 101 to 110 of about 36,315 (252)

Postoperative intravenous iron to treat iron-deficiency anaemia in patients undergoing cardiac surgery: a protocol for a pilot, multicentre, placebo-controlled randomized trial (the POAM trial)

BJA Open
Background: Iron-deficiency anaemia, occurring in 30–40% of patients undergoing cardiac surgery, is an independent risk factor for adverse outcomes. Our long-term goal is to assess if postoperative i.v. iron therapy improves clinical outcomes in patients
Justyna Bartoszko, Sarah Miles, Saba Ansari, Deep Grewal, Michelle Li, Jeannie Callum, Stuart A. McCluskey, Yulia Lin, Keyvan Karkouti   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Order of glucose infusions for all pigs.

, 2018
Order of glucose infusions for all pigs.
Reinold Ellingsen (5065916), Sven Magnus Carlsen (5065919), Konstanze Kölle (5065910), Dag Roar Hjelme (5832824), Sverre Christian Christiansen (5065907), Patrick Christian Bösch (5832821), Øyvind Stavdahl (5065913), Marte Kierulf Åm (5832815), Anders Lyngvi Fougner (5065922), Ilze Dirnena-Fusini (5832818)   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Outcome ketamine infusions: is there a difference between 1 and 3-day infusions?

, 2017
Introduction: Chronic pain impacts many aspects of a patient’s quality of life (QOL). Ketamine is a NMDA receptor antagonist that has been used for neuropathic pain.
Kuang, Xiangyu, Calhoun, Gabriela, Chin, May, Lean, Alexa, Dwarki, Karthik, Kherbache, Karim, Amdur, Richard   +6 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Subcutaneous Infusions for Hydration and Nutrition [PDF]

Subcutaneous (SC) infusions deliver fluids or medications into the body\u27s fatty tissue using small needles. They are cost-effective, easy to use, comfortable, and carry a low risk of serious complications like infections.
VanKalsbeek, Megan, Hoekman, Bryn, Johnson, Mikayla, Hulstein, Pam, Van Hauen, Laci, Dulmes, Kelsie   +5 more
core   +1 more source

Validation of High-Performance Liquid Chromatography for determination and stability assessment of dobutamine hydrochloride in pediatric intravenous therapy

Evidência
Severely ill children and newborns typically require a wide range of intravenous medications as part of specific therapies tailored to their developmental and growth characteristics.
Tatiany Calegari , Fernando Fonseca, Beatriz Alves, Glaucia da Veiga, Paulo César Rosa , Mavilde Pedreira, Maria Angélica Peterlini   +6 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A study on interactions between the insoluble fractions of different coffee infusions and major cocoa free antioxidants and different coffee infusions and dark chocolate

, 2018
This study aimed to investigate the interactions between insoluble fractions of different coffee infusions and major cocoa free antioxidants, catechin and epicatechin, as well as the interactions between different coffee infusions and dark chocolate ...
ÇELİK, ECEM EVRİM, Ecem Evrim Çelik, Vural Gökmen, GÖKMEN, VURAL   +3 more
core   +1 more source