Results 51 to 60 of about 226,248 (312)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

High pCO 2 levels affect metabolic rate, but not feeding behavior and fitness, of farmed giant mussel Choromytilus chorus [PDF]

, 2018
Indexación: Scopus.Acknowledgements. We thank Luisa Saavedra and Araceli Rodriguez-Romero for their help in the field and during laboratory activities. We also acknowledge Laura Ramajo for help with AT estimations.
Benítez, S., Duarte, C., Lagos, N.A., Lardies, M.A., Navarro, J.M., Opitz, T., Osores, S.   +6 more
core   +1 more source

Effect of carbon tetrachloride ingestion on liver and plasma triglyceride turnover rates

Journal of Lipid Research, 1964
Specific and total radioactivity of liver and serum triglycerides were determined at various times after palmitate-1-C14 injection in carbon tetrachloride-treated and control rats.
Michael C. Schotz, Nome Baker, Margarito N. Chavez   +2 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Grazing impact of the calanoid copepods Acartia spp. on the toxic dinoflagellate Alexandrium pseudogonyaulax in the western coastal waters of Korea

Frontiers in Microbiology
Marine dinoflagellate species in the genus Alexandrium are well known to produce paralytic shellfish poison as well as common coastal species with cosmopolitan distribution. However, few studies on the feeding of copepods on Alexandrium species have been
Moo Joon Lee, Yeong Jong Hwang, Yong Bum Choi, Yeong Du Yoo   +3 more
doaj   +1 more source

Surveillance of paediatric exposures to liquid laundry detergent pods in Italy [PDF]

, 2017
Objective To analyse paediatric exposures to pod and traditional laundry detergents in Italy and changes in exposure trends. Methods Analyses of a series of patients aged <5 years and exposed to laundry detergents between September 2010 and June ...
Celentano, Anna, Davanzo, Franca, Giordano, Felice, Lauria, Laura, Sesana, Fabrizio, Settimi, Laura   +5 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Salivary Secretory Immunoglobulin a secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over study

Nutrition Journal, 2011
Background Chlorella, a unicellular green alga that grows in fresh water, contains high levels of proteins, vitamins, minerals, and dietary fibers. Some studies have reported favorable immune function-related effects on biological secretions such as ...
Iemitsu Motoyuki, Shimizu Kazuhiro, Otsuki Takeshi, Kono Ichiro   +3 more
doaj   +1 more source

Physiological responses of Oxyrrhis marina to a diet of virally infected Emiliania huxleyi [PDF]

PeerJ, 2019
The coccolithophore Emiliania huxleyi forms some of the largest phytoplankton blooms in the ocean. The rapid demise of these blooms has been linked to viral infections. E.
Andrew G. Goode, David M. Fields, Stephen D. Archer, Joaquín Martínez Martínez   +3 more
doaj   +2 more sources

The metabolic responses to high carbohydrate meals with different glycemic indices consumed during recovery from prolonged strenuous exercise [PDF]

, 2005
This study investigated the metabolic responses to high glycemic index (HGI) or low glycemic index (LGI) meals consumed during recovery from prolonged exercise. 8 trained male athletes undertook 2 trials. Following an overnight fast, subjects completed a
Biscoe, Helen, Stevenson, Emma, Williams, Clyde   +2 more
core   +1 more source