Results 71 to 80 of about 226,248 (312)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The muscle protein synthetic response following corn protein ingestion does not differ from milk protein in healthy, young adults

Amino Acids
Plant-derived proteins are generally believed to possess lesser anabolic properties when compared with animal-derived proteins. This is, at least partly, attributed to the lower leucine content of most plant-derived proteins.
Philippe J. M. Pinckaers, Michelle E. G. Weijzen, Lisanne H. P. Houben, Antoine H. Zorenc, Imre W. K. Kouw, Lisette C. P. G. M. de Groot, Lex. B. Verdijk, Tim Snijders, Luc J. C. van Loon   +8 more
doaj   +1 more source

New Neutron-Capture Site in Massive Pop III and Pop II Stars as a Source for Heavy Elements in the Early Galaxy

, 2018
We propose a new neutron-capture site in early metal-poor and metal-free stars of $\sim 20$--$30 \,\mathrm{M}_\odot$ that results from proton ingestion in the He shell during late stages of the stars' lives.
Banerjee, Projjwal, Heger, Alexander, Qian, Yong-Zhong   +2 more
core   +1 more source

What goes in, must come out:combining scat-based molecular diet analysis and quantification of ingested microplastics in a marine top predator [PDF]

, 2019
Context: Microplastics (plastic particles <5 mm in size) are highly available for ingestion by a wide range of organisms, either through direct consumption or indirectly, via trophic transfer, from prey to predator.
Bennett, Kimberley A., Galloway, Tamara S., Godley, Brendan J., Lindeque, Penelope K., Nelms, Sarah E., Parry, Helen E., Santillo, David   +6 more
core   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Occupational cooling practices of emergency first responders in the United States: A survey [PDF]

, 2018
This is an accepted manuscript of an article published by Taylor & Francis in Temperature on 29/07/2018, available online: https://doi.org/10.1080/23328940.2018.1493907 The accepted version of the publication may differ from the final published version.©
ASTM International, Bonauto D, Cadarette BS, Carter R, House JR., International Organisation for Standardisation. ISO, McLellan TM, Michaels D, Occupational Safety and Health Administration, Occupational Safety and Health Administration, Prudhomme J, Taiwo OA, Watkins ER   +12 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source