Results 41 to 50 of about 480,653 (295)

KMRC011, an agonist of toll-like receptor 5, mitigates irradiation-induced tissue damage and mortality in cynomolgus monkeys

Journal of Immunotoxicology, 2020
In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 – as a countermeasure for radiation toxicities was evaluated.
Hong-Soo Lee, Doo-Wan Cho, Ji-Seok Han, Su-Cheol Han, Sang Keun Woo, Soo-Youn Jun, Woo-Jong Lee, Susie Yoon, Son-Il Pak, Sang-Jin Lee, Eunsol Seong, Eun-Jung Park   +11 more
doaj   +1 more source

Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells-Mechanisms of Remote Protection Against Hypoxia by Helium. [PDF]

, 2019
PurposeRemote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers against postischemic endothelial dysfunction.
Augustijn, Quinten JJ, Hollmann, Markus W, Konkel, Moritz, Oei, Gezina TML, Patel, Hemal H, Preckel, Benedikt, Smit, Kirsten F, Weber, Nina C   +7 more
core   +1 more source

Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction

Particle and Fibre Toxicology, 2021
Background Air pollution is a complex mixture of particles and gases, yet current regulations are based on single toxicant levels failing to consider potential interactive outcomes of co-exposures.
Quincy A. Hathaway, Nairrita Majumder, William T. Goldsmith, Amina Kunovac, Mark V. Pinti, Jack R. Harkema, Vince Castranova, John M. Hollander, Salik Hussain   +8 more
doaj   +1 more source

Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma [PDF]

, 2017
The pathophysiology of allergic asthma is driven by T-helper 2 (Th2) immune responses following aeroallergen inhalation. The mechanisms that initiate, potentiate and regulate airways allergy are incompletely characterized.
Crompton, Tessa, Furmanski, Anna L., Ross, Rosie, Standing, Ariane S.I., Yánez, Diane C.   +4 more
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Inhalation therapy in the next decade : Determinants of adherence to treatment in asthma and COPD [PDF]

, 2018
Peer reviewedPublisher ...
Amaducci, Sandro, Bacci, Elena, Baldacci, Sandra, Bartoli, Maria L., Beghi, Gianfranco M., Benfante, Alida, Brighindi, Sara, Casali, Lucio, Castiglia, Daniela, Cazzola, Mario, Celi, Alessandro, Cianchetti, Silvana, Colombo, Giorgio, Crimi, Claudia, d'Alcontres, Martina Stagno, Dente, Federico L., Di Maria, Annalisa, Di Maria, Giuseppe, Donner, Claudio F., Hui Xin, Shaylynn Yu, Latorre, Manuela, Lavorini, Federico, Maio, Sara, Mannini, Claudia, Messina, Riccardo, Paggiaro, Pier Luigi, Pignatti, Patrizia, Pistolesi, Massimo, Price, David, Scichilone, Nicola, Simoni, Marzia, Spanevello, Antonio, Tan, Shwana, Torchio, Roberto, Viegi, Giovanni, Visca, Dina, Wouters, Emiel F.M.   +36 more
core   +5 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The clinical pharmacology of intranasal l-methamphetamine. [PDF]

, 2008
BackgroundWe studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.Methods12 subjects self-administered l-methamphetamine from a nonprescription inhaler at the recommended dose (16 inhalations over 6 ...
Everhart, Tom, Foster, Elyse, Harris, Debra S, Jacob, Peyton, Jones, Reese T, McGlothlin, Dana, Mendelson, John E   +6 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Validation of the Arabic Severe Respiratory Insufficiency Questionnaire

BMC Pulmonary Medicine, 2021
Background/objectives Assessment of Health-Related Quality of Life (HRQL) in patients with chronic respiratory insufficiency requiring Home Mechanical Ventilation (HMV) requires a valid measurement tool.
Marwan F. Alawieh, Rania N. Bzeih, Mohamad F. El-Khatib, Abla M. Sibai, Lilian A. Ghandour, Salah M. Zeineldine   +5 more
doaj   +1 more source