Results 91 to 100 of about 1,979,534 (305)

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Subchronic inhalation study of toner in rats

, 2022
S.341-360A subchronic inhalation study of a special test toner was conducted by exposure of groups of F-344 SPF rats for 6h/day, 5 days/wk for 13 wk.
Mermelstein, R., Bellmann, B., Muhle, H., Morrow, P., Fuhst, R., Mohr, U., Creutzenberg, O., Kilpper, R., Takenaka, S., Koch, W., MacKenzie, J.   +10 more
core   +1 more source

Antiviral inhalation medicinal product based on interferon alpha-2b: A study of efficacy, subchronic toxicity, and toxicokinetics in rodents

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Developing high-dose interferon-based medicinal products (MPs) is particularly relevant for effective causal treatment of acute respiratory viral infections, influenza, and COVID-19 coronavirus infection.
N. V. Pankova, I. A. Leneva, I. N. Falynskova, A. V. Ivanina, E. S. Korovkina, O. E. Khuttunen, A. S. Kiryanova, S. V. Sheremetyev, D. V. Lonshakov   +8 more
doaj   +1 more source

Development and evaluation of an inhalation chamber for in vivo tests

Anais da Academia Brasileira de Ciências, 2017
The bioavailability, toxicity, and therapeutic efficacy of a drug is directly related to its administration route. The pulmonary route can be accessed by inhalation after fumigation, vaporization or nebulization.
EDUARDO R. DA SILVA, HUMBERTO R. BIZZO, PATRÍCIA D. FERNANDES, VALDIR F. DA VEIGA JUNIOR, SUZANA G. LEITÃO, DANILO R. DE OLIVEIRA   +5 more
doaj   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

PREVALÊNCIA E PREDITORES DO USO INCORRETO DOS DISPOSITIVOS INALATÓRIOS EM PACIENTES PORTADORES DE DOENÇA PULMONAR OBSTRUTIVA CRÔNICA

Revista Educação em Saúde, 2015
Objective: To determine the prevalence and predictors of incorrect use of inhalers in ambulatory patients with chronic obstructive pulmonary disease (COPD).
Giovanna Agda Moraes Mesquita, Jéssica Souza Ferro, Roberta Martins Carlos Alves, José Laerte Rodrigues da Silva Júnior, Carolina Gomes Machado   +4 more
doaj  

E-cigarettes: Learnings for inhalation scientists: How studying e-cigarette technology may lead to new inhalation therapies

, 2016
ECs share a common purpose with conventional pharmaceutical inhalation devices: they produce aerosols intended to be orally inhaled into the respiratory tract.
Kwok, PCL, Hou, L, Rogueda, P
core  

Repeated inhalation of crack-cocaine affects spermatogenesis in young and adult mice

, 2012
To investigate the effects of repeated crack-cocaine inhalation on spermatogenesis of pubertal and mature Balb/c mice, ten young (Y-ex) and ten adult (A(ex)) Balb/c mice were exposed to the smoke from 5 g of crack with 57.7% of pure cocaine in an ...
Santos, A. B. G., Hage, M., Medeiros, M. C. R., Zorzetto, J. C., Garcia, R. C. T., Bueno, H. M. S., Pieri, P., Yonamine, M., Saldiva, P. H. N., Pires, A., Hallak, J.   +10 more
core   +1 more source

Formulation pre-screening of inhalation powders using computational atom-atom systematic search method. [PDF]

, 2015
The synthonic modeling approach provides a molecule-centered understanding of the surface properties of crystals. It has been applied extensively to understand crystallization processes.
Jaffari, Sara, Soufian, Majeed, Roberts, Kevin J., Darragh Murnane (1348947), Soufian, M, Jaffari, S, Vasuki Ramachandran, Forbes, Ben, Elizabeth Collins, Jonathan Pickering, Ramachandran, V, Martin, GP, Robert B. Hammond (1348938), Klimentina Pencheva, Gary P. Martin (1348953), Collins, E, Vasuki Ramachandran (1348941), Collins, Elizabeth, Pencheva, K, Roberts, KJ, Elizabeth Collins (1348959), Klimentina Pencheva (1348962), Ben Forbes, Hammond, Robert B., Gary P. Martin, Pickering, Jonathan, Murnane, Darragh, Robert B. Hammond, Kevin J. Roberts (1348965), Ramachandran, Vasuki, Martin, Gary P., Jonathan Pickering (1348968), Kevin J. Roberts, Murnane, D, Sara Jaffari (1348956), Darragh Murnane, Sara Jaffari, Hammond, RB, Forbes, B, Majeed Soufian (1348944), Majeed Soufian, Pickering, J, Ben Forbes (1348950), Pencheva, Klimentina   +43 more
core   +1 more source