Results 151 to 160 of about 301,988 (285)

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li   +3 more
wiley   +1 more source

Refining OVCAR‐3 xenograft models of peritoneal carcinomatosis in nu/nu mice: Comparative intraperitoneal implantation strategies and the role of basement membrane matrix

open access: yesAnimal Models and Experimental Medicine, EarlyView.
A refined murine model of advanced ovarian cancer was established by comparing localized preperitoneal implantation and intraperitoneal injection of OVCAR‐3Luc cells. While localized implantation showed limited tumor persistence, intraperitoneal delivery with BME produced sustained diffuse dissemination confirmed by BLI and histology, providing a ...
M. Teresa Perelló‐Trias   +5 more
wiley   +1 more source

Evaluating The Effects of Dexmedetomidine on the Quality of Pediatric Recovery Post-Inhalation Anesthesia

open access: yes
Inhalation agents are one common way to deliver anesthesia to children since they are often induced via mask inhalation before venous access is obtained. Delirious behavior and agitated states during emergence and postoperative nausea and vomiting (PONV)
Brooke E. Young; Hannah N. Fries
core   +1 more source

Animal stroke models and outcome evaluation: A review

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba   +2 more
wiley   +1 more source

EFFECT OF NITROUS OXIDE INHALATION ON CHANGES IN SENSORY BLOCK IN PATIENTS UNDERGOING SPINAL ANESTHESIA

open access: yes, 2003
Introduction: Spinal Anesthesia is a successful method for most surgical procedures on lower extremities and lower abdomen. Occasionally the duration of sensory blockade is shorter than the duration of the surgical procedures resulting in painful stress ...
SEYED JALAL HASHEMI   +2 more
core  

A self‐retaining mouth prop for intraoral access during periodontal surgery in rat models: A technical note

open access: yesAnimal Models and Experimental Medicine, EarlyView.
A mouth prop designed to mimic the oral cavity of rats was made that provided stable, self‐retaining retraction, thereby facilitating oral surgery on rodents. Compared to conventional methods, it decreased surgical time, operator fatigue, and slippage. Its use led to higher efficiency and fewer complications and it was cost effective to produce.
Saravanan Sampoornam Pape Reddy   +5 more
wiley   +1 more source

Mechanisms of natural compounds in treating inhalation anesthesia-induced cognitive dysfunction. [PDF]

open access: yesFront Pharmacol
Han Z   +7 more
europepmc   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

open access: yesAnnals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes   +6 more
wiley   +1 more source

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