Results 271 to 280 of about 73,925 (353)

Injectable Self‐Polymerizing Hydrogel as Bone Filler for Bone Defect Treatment

open access: yesMacromolecular Bioscience, EarlyView.
This study presents a multifunctional composite as an innovative bone cement substitute. By combining silver–hydroxyapatite–polydopamine to form a dynamic redox system that accelerates free radical polymerization, the material achieves smooth injectability.
Xiaozhuo Wu   +4 more
wiley   +1 more source

Dietary Blueberry Supplementation Attenuates the Effects of an Ultra‐Processed Food Cafeteria Diet on Weight Gain and Metabolic Parameters, Enhancing Nutrigenomic Profiles in C57BL/6 Mice

open access: yesMolecular Nutrition &Food Research, EarlyView.
1. Experimental Design (left panel) • Icons: ∘ Three C57BL/6 mice groups ∘ Control group (Standard chow) ∘ Cafeteria diet (cookies, soda, sausage, condensed milk, chow) ∘ CAFD + Blueberry (CAFD + BB smoothie and pellets) • Group Labels: ∘ Control (C): Standard diet ∘ CAFD: Cafeteria diet + SD ∘ BB: CAFD + BB • Duration: 16 weeks • Arrow pointing to ...
Felipe Mateus Pellenz   +18 more
wiley   +1 more source

The Effect of Anti‐3‐Hydroxy‐3‐Methylglutaryl‐CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice

open access: yesMuscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms.
Sarah Julien   +6 more
wiley   +1 more source

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

open access: yesNeuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai   +3 more
wiley   +1 more source

Glucocorticoid‐Induced TNFR‐Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children

open access: yesPediatric Discovery, EarlyView.
Our study demonstrates elevated GITRL expression in HDM‐exposed dendritic cells (in vitro), murine asthma models, and pediatric asthma patients, and reveals a direct association between GITRL levels and disease severity in children. ABSTRACT Currently, there are no reliable pediatric biomarkers for assessing the severity of asthma. Therefore, the study
Yuehan Li   +7 more
wiley   +1 more source

Atomic Force Microscopy‐Based Nanomechanical Signatures for Staging Classification and Drug Response in Pulmonary Fibrosis

open access: yesSmall, EarlyView.
Atomic Force Microscopy (AFM) reveals nanomechanical fingerprints (NMFs) that track the progression of pulmonary fibrosis (PF) and response to therapy. These NMFs correlate with collagen I content and gene expression, offering a novel biomarker for disease staging and treatment monitoring.
Andreas Stylianou   +11 more
wiley   +1 more source

Targeted Nanocomplex Delivery for Protecting Vascular Integrity and Enhancing Anticancer Effects in Hepatocellular Carcinoma

open access: yesSmall Science, EarlyView.
Herein, a liver‐targeted nanohybrid formulation, SGLC/DOX@AG, is developed to enhance doxorubicin delivery and reduce vascular toxicity in hepatocellular carcinoma (HCC) treatment. Incorporating an albumin–glucosamine lipid complex, the system shows potent anticancer effects and minimized side effects across in vitro, in vivo, and cancer‐on‐a‐chip ...
Hyelim Kim   +11 more
wiley   +1 more source

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