Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Advanced Functional Materials, EarlyView.Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source
Enzyme‐Regulated Extended Swelling of Hydrogels for Dehiscence‐Less Tissue Expansions
Advanced Functional Materials, EarlyView.An interpenetrating hydrogel network with swelling under regulation by enzymatic degradation (INSURED) is fabricated to avoid dehiscence. INSURED remains structurally intact post‐implantation, while HYAL injection enables control over the onset and rate of swelling.
Byung Ik Park +10 more
wiley +1 more source
Effect on thermoregulatory responses in patients undergoing a tympanoplasty in accordance to the anesthetic techniques during PEEP: a comparison between inhalation anesthesia with desflurane and TIVA [PDF]
Korean Journal of Anesthesiology, 2014 BackgroundIt has been known that positive end-expiratory pressure (PEEP) increases the vasoconstriction threshold by baroreceptor unloading. We compared the effect on the thermoregulatory responses according to anesthetic techniques between an inhalation
Ki Tae Jung +8 more
doaj +1 more source
Qualitative and Quantitative Characteristics of the Electroencephalogram in Normal Horses during Administration of Inhaled Anesthesia. [PDF]
, 2015 BackgroundThe effects of anesthesia on the equine electroencephalogram (EEG) after administration of various drugs for sedation, induction, and maintenance are known, but not that the effect of inhaled anesthetics alone for EEG recording.ObjectiveTo ...
Aleman, M +8 more
core +1 more source
3D‐Printed Soft Magnetoactive Origami Actuators
Advanced Functional Materials, EarlyView.Soft magnetoactive films are 3D‐printed using ink with up to 75 wt.% ferromagnetic particles and dual UV/heat curing, then integrated with various origami structures. The films are flexible, magnetically responsive, and programmable, enabling flexible integration with origami without hindering shape‐changeability.
Sen Zhang +6 more
wiley +1 more source
Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals
Advanced Functional Materials, EarlyView.This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee +4 more
wiley +1 more source
Immobilization and Anesthesia of African lion (Panthera leo) 5 Cases [PDF]
Iranian Journal of Veterinary Surgery, 2007 Case Description- Five lions (one female and 4 male) were presented for diagnostic and surgical treatment (wound management, castration and radiography). Immobilization or anesthesia was necessary to complete the procedure.
Nasser Vesal +1 more
doaj
Diagnosis of dental problems in pet rabbits (Oryctolagus cuniculus) [PDF]
, 2008 Dental problems are very common in pet rabbits. To establish a correct diagnosis of rabbit dental pathology, a general knowledge of normal dental anatomy and physiology is necessary.
De Rycke, Lieve +5 more
core +1 more source
Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration [PDF]
, 2014 Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated ...
A Tidholm +46 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang +14 more
wiley +1 more source