Results 221 to 230 of about 41,522 (262)

Inhaled corticosteroids—effect on bone?

Respiratory Medicine, 1993
Asthmatic patients receiving long-term therapy with oral prednisolone have been found to have an increased incidence of vertebral fractures. Measurements of bone density have shown that diminished bone density is associated with administration of oral corticosteroids rather than with the disease.
openaire   +2 more sources

Systemic effects of inhaled corticosteroids

Current Opinion in Pulmonary Medicine, 2012
Although inhaled corticosteroids (ICSs) are the mainstay of therapy in asthma, their use raises certain safety concerns. We review the articles appearing in the last year which have addressed the safety of ICSs when used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).Recent studies suggest that patients with asthma as ...
Pierre, Ernst, Samy, Suissa
openaire   +2 more sources

Inhaled Corticosteroids in Children

Drug Safety, 1993
Inhaled corticosteroids are effective for the treatment of asthma. Because of the appreciation of the importance of airway inflammation in the pathogenesis of the disease, these drugs are being used more frequently not only in severe but also in moderate asthma.
BONER, Attilio, PIACENTINI, Giorgio
openaire   +3 more sources

[Inhaled corticosteroids for COPD].

Nederlands tijdschrift voor geneeskunde, 2003
Over 60% of patients with COPD are treated with inhaled corticosteroids (ICS), even though their use is still subject to debate. The inflammatory process in the lungs of patients with COPD is dominated by macrophages, CD8+ T-lymphocytes, neutrophilic granulocytes and mast cells, as well as an increased production and/or concentration of IL-8, TNF-alpha
openaire   +2 more sources

Advances in inhaled corticosteroid pharmacology

Allergy and Asthma Proceedings, 2007
Inhaled corticosteroids have been the backbone of asthma therapy for the past 20 plus years. Although they have, for the most part, been effective in controlling asthma symptoms and preventing exacerbations, not all patients are universally responsive to their beneficial effects.
openaire   +2 more sources

Inhaled Corticosteroids in Airways Disease

2009
I. Introduction Asthma therapy was revolutionized in the early 1970s by the introduction of inhaled corticosteroid (ICS) therapy. ICS therapy has subsequently proved to be the most effective anti-inflammatory treatments for asthma control. Because of the success of ICS for asthma and the realization that chronic obstructive pulmonary disease (COPD) is ...
Adcock I. M., Chung K. F., CARAMORI, Gaetano   +2 more
openaire   +4 more sources

Pharmacokinetics and pharmacodynamics of inhaled corticosteroids

Journal of Allergy and Clinical Immunology, 1998
There are significant differences in the pharmacokinetic properties of inhaled corticosteroids currently used in medical practice. All are rapidly cleared from the body but they show varying levels of oral bioavailability and more importantly variation in the rate of absorption after inhalation. Oral bioavailability is lowest for fluticasone propionate,
H, Derendorf, G, Hochhaus, B, Meibohm, H, Möllmann, J, Barth   +4 more
openaire   +2 more sources

Effect of Inhaled Corticosteroids on Growth

Pediatrics, 2001
To the Editor. I read with interest the meta-analysis of Sharek and Bergman1 regarding the effect of inhaled corticosteroids (ICS) on growth, and felt it was important to address 2 issues in response. First, the authors' analysis of the growth effect seen during treatment with fluticasone propionate (FP) 200 μg/day indicated a small but statistically
openaire   +2 more sources

Safety of inhaled corticosteroids in children

Pediatric Pulmonology, 2002
AbstractInhaled corticosteroids (ICS) are now first‐line therapy for persistent asthma in children. The major safety concerns of long‐term ICS therapy for childhood asthma are potential effects on adrenal function, growth, and bone mass. Dosage, type of inhaler device, and individual drug characteristics influence systemic effects of ICS.
openaire   +2 more sources

Asthma, growth and inhaled corticosteroids

Respiratory Medicine, 1993
Linear growth can be divided into three phases: during infancy it is influenced mainly by nutrition; thereafter throughout childhood it comes under hormonal control; puberty constitutes the third phase. The pubertal growth spurt, which may account for up to 30 cm of linear growth, results from an increase in growth hormone pulse amplitude that is ...
openaire   +2 more sources